| Figure 5: Representative PLGA-based nanoparticulate dosage forms. (A)
PEGylated micelle (eg, PEG-PLGA block copolymeric micelle), (B) polyplex
(eg, DNA-PEI-PLGA), (C) PEGylated PLGA nanoparticle, (D) core-shell
type nanoparticle (eg, PEGylated lipid-PLGA hybrid nanoparticle), (E) cell
membrane-PLGA hybrid nanoparticle (eg, PLGA nanoparticles encased by
red blood cell), (F) polymersome (eg, PEG-PLGA block copolymeric vesicle),
and (G) magnetic PLGA particle either conjugated with gadolinium-chelate or
laden with magnetite (e.g.theranostics) [54]. |
Note: All of these nanoparticulate carriers can be further derivatized by cellrecognizable
ligands