| Transcription factors |
Inflammatory mediators |
| Activating transcription factor-3 ↓ |
C-reactive protein ↓ |
| Activator protein-1 ↓ |
Interleukin-1β ↓ |
| β-catenin ↓ |
Interleukin-2 ↓ |
| CREB-binding protein ↓ |
Interleukin-5 ↓ |
| C/EBP homologous protein ↓ |
Interleukin-6 ↓ |
| Electrophile response element ↑ |
Interleukin-8 ↓ |
| Early growth response gene-1 ↓ |
Interleukin-12 ↓ |
| Hypoxia inducible factor-1α↓ |
Interleukin-18 ↓ |
| Nuclear factor κ-B ↓ |
Interferon-γ ↓ |
| Notch-1 ↓ |
Inducible nitric oxide synthase ↓ |
| NFE2 related factor ↑ |
5-Lipoxygenase ↓ |
| p53↑ |
Monocyte chemoattractant protein ↓ |
| Peroxisome-proliferator-activated receptor -γ ↑ |
Migration inhibition protein ↓ |
| Specificity protein-1 ↓ |
Macrophage inflammatory protein-1α↓ |
| STAT-1 ↓ |
Prostate specific antigen ↓ |
| STAT-3 ↓ |
|
| STAT-4 ↓ |
Protein kinases |
| STAT-5 ↓ |
Autophosphorylation-activated protein kinase ↓ |
| Wilms' tumor gene 1 ↓ |
Ca2+, phospholipid-dependent protein kinase C ↓ |
| |
c-jun N-terminal kinase ↓ |
| Enzymes |
cAMP-dependent protein kinase ↓ |
| Acetylcholinesterase ↓ |
CSN-associated kinase ↓ |
| Aldose reductase ↓ |
EGF receptor-kinase ↓ |
| Arylamine N-acetyltransferases-1 ↓ |
Extracellular receptor kinase ↓ |
| Beta-site APP-cleaving enzyme-1 ↓ |
Focal adhesion kinase ↓ |
| CD13 ↓ |
IL-1 receptor-associated kinase ↓ |
| DNA polymerase I ↓ |
IκB kinase ↓ |
| DNA topoisomerase-II ↓ |
Janus kinase ↓ |
| GTPase (microtubule assembly) ↓ |
Mitogen-activated protein kinase ↓ |
| Glutathione reductase ↓ |
pp60c-src tyrosine kinase ↓ |
| Glutathione-peroxidase ↓ |
Phosphorylase kinase ↓ |
| Glutathione S-transferase ↑ |
Protein kinase A ↓ |
| Hemeoxygenase-1 ↑ |
PI3K-Akt ↓ |
| Ca2+-dependent ATPase ↓ |
Protamine kinase ↓ |
| Inosine monophosphate dehydrogenase ↓ |
|
| 17β-HSD3 ↓ |
Drug resistance proteins |
| Ornithine decarboxylase ↓ |
Multi-drug resistance protein-1 ↓ |
| Monoamine oxidase ↓ |
Multi-drug resistance protein-2 ↓ |
| NADP(H):quinoneoxidoreductase -1 ↓ |
|
| Phospholipase D ↓ |
Adhesion molecules |
| Thioredoxinreductase 1 ↓ |
Intracellular adhesion molecule-1 ↓ |
| Telomerase ↓ |
Endothelial leukocyte adhesion molecule-1 ↓ |
| Ubiquitin isopeptidases ↓ |
Vascular cell adhesion molecule-1 ↓ |
|
Growth factors |
Cell-survival proteins |
| Connective tissue growth factor ↓ |
B-cell lymphoma protein-xL ↓ |
| Epidermal growth factor ↓ |
Cellular FLICE-like inhibitory protein ↓ |
| Fibroblast growth factor ↓ |
Inhibitory apoptosis protein ↓ |
| HER2 ↓ |
X-linked IAP ↓ |
| Hepatocyte growth factor ↓ |
|
| Platelet derived growth factor ↓ |
Chemokines and chemokine receptor |
| Tissue factor ↓ |
Chemokine ligand 1 ↓ |
| Transforming growth factor-β1 ↓ |
Chemokine ligand 2 ↓ |
| |
Chemokine receptors 4 ↓ |
| Receptors |
Invasion and angiogenesis biomarkers |
| Androgen receptor ↓ |
Matrix metalloproteinase-9 ↓ |
| Aryl hydrocarbon receptor ↓ |
Urokinase-type plasminogen activator ↓ |
| Death receptor-5 ↓ |
Vascular endothelial growth factor ↓ |
| EGF-receptor ↓ |
|
| Endothelial protein C-receptor ↓ |
Others |
| Estrogen receptor-α ↓ |
cAMP response element binding protein ↓ |
| Fas ↑ |
DNA fragmentation factor 40-kD subunit ↑ |
| Histamine 2- receptor ↓ |
Fibrinogen ↓ |
| Interleukin 8-receptor ↓ |
Ferritin H and L ↓ |
| Inositol 1,4,5-triphosphate receptor ↓ |
Heat-shock protein 70 ↑ |
| Integrin receptor ↓ |
Iron regulatory protein ↓ |
| Low density lipoprotein-receptor ↑ |
Prion fibril ↓ |
| Transferrin receptor 1 ↓ |
|
|
Cell-cycle regulatory proteins |
|
| Cyclin D1 ↓ |
|
| Cyclin E ↓ |
|
| c-Myc ↓ |
|
| p21 ↓ |
|
