Species Routea Dose Plasma/Tissue Levels mice i.p. 100 mg/kg plasma 2.25 µg/mL       intestine 117 ± 6.9 µg/g       spleen 26.1 ± 1.1 µg/g       liver 26.9 ± 2.6 µg/g       kidney 7.5 ± 0.08 µg/g       brain 0.4 ± 0.01 µg/g mice oral 100 mg/kg plasma 0.22 µg/mL mice i.p. 100 mg/kg plasma 25 ± 2 nmol/mL       intestinal mucosa 200 ± 23 nmol/g       liver 73 ± 20 nmol/g       brain 2.9 ± 0.4 nmol/g       heart 9.1 ± 1.1 nmol/g       lungs 16 ± 3 nmol/g       muscle 8.4 ± 6 nmol/g       kidney 78 ± 3 nmol/g rat oral 2 g/kg stomach 53.3 ± 5.1 (µg/g)       small intestine 58.6 ± 11.0 (µg/g)       cecum 51.5 ± 13.5 (µg/g)       large intestine 5.1 ± 2.5 (µg/g) rat oral 340 mg/kg serum 6.5 ± 4.5 nM rat oral 1g/kg serum 0.5 µg/mL rat oral 2 g/kg serum 1.35 ± 0.23 µg/mL rat oral 500 mg/kg plasma 0.06 ± 0.01 µg/mL rat i.v. 10 mg/kg plasma 0.36 ± 0.05 µg/mL human oral 2 g/kg serum 0.006 ± 0.005 µg/mL human oral 4–8 g serum 0.4–3.6 µM human oral 10 g serum 50.5 ng/mL human oral 12 g serum 51.2 ng/mL human oral 3.6 g plasma 11.1 ± 0.6 nmol/mL human oral 0.4–3.6 g colorectum 7–20 nmol/g aKey: i.p: intreperitoneal; i.v.: intraveneous

Table 2: Serum and tissue levels of curcumin in rodents and humans after different routes of administration [1].

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