| Grade | Description (EORTC/RTOG criteria) | Before instillation | 3 months after instillation | 
      
        | I | Slight epithelial atrophy Minor    telangiectasia (microscopic hematuria)
 | - | 9/20 (45%) | 
      
        | II | Moderate frequency Generalized    telangiectasia
 Intermittent    macroscopic hematuria
 | 6/20 (30%) | 11/20 (55%) | 
      
        | III | Severe frequency and dysuria Severe    generalized telangiectasia (often with petechiae)
 Frequent    hematuria
 Reduction in    bladder capacity (<150 cc)
 | 14/20 (70%) | - |