Grade Description (EORTC/RTOG criteria) Before instillation 3 months after instillation
I Slight epithelial atrophy
Minor telangiectasia (microscopic hematuria)
- 9/20 (45%)
II Moderate frequency
Generalized telangiectasia
Intermittent macroscopic hematuria
6/20 (30%) 11/20 (55%)
III Severe frequency and dysuria
Severe generalized telangiectasia (often with petechiae)
Frequent hematuria
Reduction in bladder capacity (<150 cc)
14/20 (70%) -
Table 2: EORTC/RTOG radiation induced cystitis as late toxicity, before and after cystistat instillation (chi2<0.01).
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