inhaled administration of FF

	Parameter	Effect	Point Estimate	90% CI
Single Dose	AUC(0-α)	Log (dose)	1.040	(0.956, 1.123)
	AUC_(0-12)	Log (dose)	0.775	(0.722, 0.829)
	C_max	Log (dose)	0.477	(0.416, 0.539)
Repeat Dose	AUC_(0-4)	Log (dose)	0.758	(0.690, 0.827)
Repeat Dose	C_max	Log (dose)	0.606	(0.538, 0.674)

AUC = area under the curve; CI = confidence interval; C_max = maximum plasma concentration; FF = fluticasone furoate

Table 1: Results of power model assessment of FF dose proportionality following
a single and repeat inhaled administration of FF [dose proportionality Study 1].

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