Results of assessment of FF bioequivalence

Parameter	Treatment Comparison	Adjusted Geometric Means	Ratio of Adjusted Geometric Means	90% CI of the Ratio
AUC(0-α)	FF 400 single-strip/FF 400 two-strip	1144.7/889.5	1.29	(1.14, 1.46)
AUC(0-α)	FF 400 single-strip/FF/VI 400/50	1144.7/714.8	1.60	(1.37, 1.87)
AUC_(0-t’)	FF 400 single-strip/FF 400 two-strip	560.2/458.0	1.22	(1.16, 1.29)
AUC_(0-t’)	FF 400 single-strip/FF/VI 400/50	560.2/401.1	1.40	(1.31, 1.49)
AUC_(0-t)	FF 400 single-strip/FF 400 two-strip	723.0/531.6	1.36	(1.23, 1.50)
AUC_(0-t)	FF 400 single-strip/FF/VI 400/50	723.0/441.2	1.64	(1.44, 1.87)
C_max	FF 400 single-strip/FF 400 two-strip	67.84/60.08	1.13	(1.07, 1.20)
C_max	FF 400 single-strip/FF/VI 400/50	67.84/47.75	1.42	(1.33, 1.52)

AUC = area under the curve; CI = confidence interval; C_max = maximum plasma concentration; FF = fluticasone furoate

Table 2: Results of assessment of FF bioequivalence following single inhaled administration of FF [bioequivalence Study 2].

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