Formula Drug DMSO PEG 400 Tween 80 Cremophor EL 1-methyl-2-pyrrolidones Tween 20 Labrasol Capryol 90 Plurololeique Labrafac Water Appearance 1 h 5 h 24 h 1 10 mg 50 μL 450 μL                 500 μL ppt ppt ppt* 2 10 mg 50 μL     300 μL             500 μL clear ppt ppt 4 10 mg 50 μL   450 μL               500 μL clear ppt ppt 6 10 mg 50 μL         450 μL         500 μL clear ppt ppt 7 10 mg 50 μL   300 μL       150 μL       500 μL clear ppt ppt 9 10 mg 25 μL           380 μL   95 μL   500 μL clear ppt ppt 10 10 mg 50 μL 100 μL 350 μL               500 μL clear clear ppt 24 10 mg             250 μL     250 μL 500 μL clear clear ppt 29 5 mg             700 μL       300 μL clear clear clear 39 5 mg             500 μL   70 μL 30 μL 400 μL clear clear ppt 45 10 mg         100 μL   200 μL 100 μL   100 μL 500 μL clear clear ppt 50 10 mg             400 μL 100 μL     400 μL clear clear ppt 58 5 mg         35 μL   500 μL       465 μL clear clear clear 59** 5 mg         35 μL   465 μL       500 μL clear clear clear *Precipitation **The formulation was selected for further long-term stability and oral bioavailability test

Table 2: Compositions of selected oral etravirine liquid formulations.

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