Parameter (unit)
Test Product
Reference Product
C
max
(ng/mL)
215 ± 69,9
196,9 ± 58,2
AUC
0-t
(ng.h/mL)
3849,6 ± 1664,3
3605,4 ± 1412,1
AUC
0-∞
(ng.h/mL)
4233,7 ± 2076,8
3905,8± 1490,9
T
max
(h)
6,3± 1,4
6,4± 1,7
K
e
(1/h)
0,079± SD
0,068± SD
T½(h)
10,5± SD
11,5± SD
Table 3:
Pharmacokinetic parameters of desvenlafaxine succinate for Test product (Styma
®
) and Reference product (Pristiq
®
) followed by a 100 mg single oral postprandial dose. Mean and Standard Deviation are presented.
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