|
Parameter (Units)
|
Linezolid 600 mg tablet
(Reference treatment)
N=20
|
Linezolid 600 mg
oral suspension
(Test treatment)
N=20
|
|
AUCinf (µg*h/mL), mean (± SD)*
|
112.6 (24.9)
|
109.2 (21.7)
|
|
AUClast (µg*h/mL), mean (± SD)*
|
112.0 (24.7)
|
108.9 (21.7)
|
|
Cmax (µg/mL), mean (± SD)*
|
13.7 (3.5)
|
15.5 (3.5)
|
|
Tmax (h), median (range)
|
1.50 (0.5–4.0)
|
0.63 (0.5–2.0)
|
|
t1/2 (h), mean (± SD)*
|
5.13 (0.92)
|
5.08 (0.70)
|
AUCinf, area under plasma concentration–time curve from time zero extrapolated
to infinite time; AUClast, area under plasma concentration–time curve from time
zero to the time of the last quantifiable concentration; Cmax, maximum plasma
concentration; SD: Standard Deviation; t1/2, elimination half-life; Tmax, time for
maximum plasma concentration.
*Arithmetic mean. |
