Stress conditions % Drug recovered % Drug decomposed Theoretical plates Tailing factor
Rosuvastatin
Standard drug 100 0 8052.207 1.407
Acidic degradation 93.61 6.39 8410.217 1.429
Alkaline degradation 98.40 1.60 8352.050 1.436
Oxidative degradation 94.34 5.66 8480.252 1.430
Thermal degradation 92.74 7.26 8087.685 1.406
Photolytic degradation 91.85 8.15 8456.438 1.428
Ezetimibe
Standard drug 100 0 10793.731 1.392
Acidic degradation 97.39 2.61 10966.786 1.413
Alkaline degradation 5.27 94.73 9279.186 1.476
Oxidative degradation 99.42 0.58 10824.863 1.469
Thermal degradation 96.77 3.23 10667.446 1.390
Photolytic degradation 93.70 6.30 10777.534 1.380
Table 8: Forced degradation studies of Rosuvastatin and Ezetimibe.
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