Parameter Test* Reference† Full data set     Cmax, μg/ml 3.57 (0.85) 3.65 (0.94) AUC0–t, μg·h /ml 33.91 (5.40) 34.87 (6.39) AUC0–∞, μg·h/ml. 43.73 (6.67) 52.96 (46.91) Tmax, h  1.15 (0.75) 1.51 (1.19) t1/2, h 11.25 (1.58) 14.12 (15.79) Reduced data set     Cmax, μg/ml 3.57 (0.85) 3.65 (0.94) AUC0–t, μg·h /ml 33.91 (5.40) 33.94 (5.58) AUC0–∞, μg·h/ml. 43.73 (6.67) 43.31 (7.35) Tmax, h  1.15 (0.75) 1.51 (1.19) t1/2, h 11.25 (1.58) 10.85 (1.70) The full data set includes all of the subjects, including all of their concentration values. The reduced data set includes all of the subjects, with the single exception of the last concentration value (72-hours, reference formulation) for the subject identified as number 12. AUC0–t =AUC from time 0 (baseline) to the last measurable concentration; AUC0–∞= AUC from baseline extrapolated to infinity. *Trademark: Zinolox 4G® (Laboratorios Liomont, S. A. de C. V., Mexico City, Mexico). †Trademark: Avelox® (Bayer de México, S. A. de C. V., Mexico City, Mexico).

Table 1: Pharmacokinetic parameters of a test and a reference formulation of oral moxifloxacin 400 mg after a single administration in healthy Mexican adult subjects (n = 26). Values are mean (SD).

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