| |
CLR formulations |
| Parameters |
Clarithromycin (test) |
Klaricid (reference) |
| 1×500 mg Tablet |
|
|
| Cmax, ng/ml |
2886.67 (550.21) |
3206.25 (489.39) |
| Tmax, h |
3.08 (1.00) |
2.75 (1.27) |
| t1/2, h |
6.08 (1.51) |
6.57 (1.74) |
| t1/2α, h |
1.48 (0.91) |
1.11 (0.71) |
| K, h-1 |
0.13 (0.07) |
0.11 (0.03) |
| Ka, h-1 |
0.61 (0.30) |
0.85 (0.49) |
| Vd, L |
0.53 (0.21) |
0.63 (0.31) |
| Cl, L/h |
0.06 (0.02) |
0.06 (0.02) |
| MRT, h |
9.68 (1.57) |
10.31 (2.01) |
| AUC0-t,ng/ml/h |
26950.77 (8752.44) |
28892.90 (6011.71) |
| AUC0-∞,ng/ml/h |
29364.01 (9637.34) |
32018.86 (7859.30) |
| AUMC0-∞,ng/ml |
292368.63 (117726.66) |
338464.50 (135732.49) |
| 2×250 mg Tablet |
|
|
| Cmax, ng/ml |
2825.00 (649.70) |
2491.25 (495.04) |
| Tmax, h |
2.54 (0.66) |
2.67 (0.58) |
| t1/2, h |
7.17 (1.28) |
7.61 (1.29) |
| t1/2α, h |
1.94 (1.16) |
2.26 (1.10) |
| K, h-1 |
0.10 (0.02) |
0.09 (0.01) |
| Ka, h-1 |
0.52 (0.32) |
0.42 (0.28) |
| Vd, L |
0.53 (0.11) |
0.57 (0.14) |
| Cl, L/h |
0.05(0.01) |
0.05 (0.01) |
| MRT, h |
10.96 (1.40) |
11.80 (1.65) |
| AUC0-t,ng/ml/h |
23479.73 (5185.31) |
23072.22 (5062.69) |
| AUC0-∞,ng/ml/h |
26144.41 (5294.93) |
26301.34 (5670.49) |
| AUMC0-∞,ng/ml |
282799.95 (53362.86) |
311297.68 (85460.60) |
| 500 mg Suspension |
|
|
| Cmax, ng/ml |
3152.92 (523.90) |
3138.42 (691.61) |
| Tmax, h |
2.54 (0.81) |
2.17 (0.58) |
| t1/2, h |
7.92 (2.03) |
8.75 (2.61) |
| t1/2α, h |
1.52 (0.86) |
0.93 (0.40) |
| K, h-1 |
0.09 (0.02) |
0.08 (0.02) |
| Ka, h-1 |
0.57 (0.30) |
0.90 (0.46) |
| Vd, L |
0.84 (0.52) |
0.96 (0.65) |
| Cl, L/h |
0.07 (0.02) |
0.07 (0.03) |
| MRT, h |
11.97 (3.32) |
12.61 (3.75) |
| AUC0-t,ng/ml/h |
29494.56 (7253.05) |
28735.19 (7765.30) |
| AUC0-∞,ng/ml/h |
34883.18 (12014.64 ) |
34749.15 (12727.01) |
| AUMC0-∞,ng/ml |
445350.95 (288747.70) |
478120.61 (327080.66) |
|
