| Population |
|
AUC(0–24 h)
(mg´h/L) |
Cmax (0–24 h)
(mg/L) |
AUC(0-∞)
(mg´h/L) |
tmax
(hours) |
t1/2
(hours) |
Japanese
(N=32) |
Mean (SD); |
253.0 (64.3) |
24.5 (11.2) |
262.9 (62.9) |
5.3* |
3.8* |
| Range |
147.5–387.2 |
12.1–57.4 |
157.8–391.6 |
2.6–14.1 |
1.5–10.7 |
Caucasians
(N=35) |
Mean (SD); |
242.5 (58.7) |
22.6 (8.3) |
247.2 (57.6) |
4.6* |
3.2* |
| Range |
166.4–398.3 |
14.4–54.2 |
169.5–399.2 |
3.1–12.1 |
2.1–6.8 |
| |
Ratio** |
1.039 |
1.045 |
n.d. |
n.d. |
n.d. |
| 90% CI |
0.943–1.143 |
0.906–1.206 |
n.d. |
n.d. |
n.d. |
|
| n.d., not determined, *median, **estimated mean ratio between Japanese and Caucasians. |
| Table 1: Pharmacokinetics in Japanese and Caucasian Subjects after Injection of rhGH. |
