Effective Permeability   Coefficient X 10-4 cm/min        
Compound Frogd humana Ratb CACO-2c PAMPAc BCSa Frogd Humana FA % Kax10-4/min
Metaprolol 0.3 ± 0.052 1.3 ± 10-4 0.20 ± 0.04 0.23 0.035 H H 96 1.2
Naproxen 1.865 ± 0.17 8.3 ± 4.8 1.19  ±  0.12 0.39 0.106 H H 100 7.2
Ranitidine 0.094 ± 0.07 0.27 ± 0.06 0.073  ± 0.06 0.004 0.005 L L 50 0.37
Cimetidine 0.129 ± 0.06 0.3 ± 0.05 0.105  ± 0.06 0.007 0.0 L L 60 0.516
Ketoprofen 2.22 ± 0.23 8.4  ±  3.3 1.55  ± 0.34 - 0.167 H H 100 8.88
Hydrochlorthiazide 0.013 ± 0.002 0.04 ± 0.05 0.001 ± 0.001 0.005 0.0 L L 67 0.052
Verapamil 1.186 ± 0.08 6.7 ± 2.9 0.65  ±  0.05 0.117 0.074 H H 100 4.74
Atenolol 0.083 ± 0.05 0.2 ± 0.2 0.060  ± 0.06 0.002 0.0 L L 50 0.332
Antipyrine 1.325 ± 0.12 4.5 ± 2.5 0.96  ±  0.13 0.28 0.132 H H 100 5.3
Fluvastatin 0.827 ± 0.07 2.4  ±  1.8 0.50.04 -- - H H 98 3.3
Furosemide 0.0124 ± 0.03 0.04 ± 0.04 0.117  ±  0.08 0.001 0.006 L L 61 0.05
Ciprofloxacin 0.2 ± 0.85 - 0.155 ± 1.98 0.028 0.0017 L L - 0.8
a. Winiwarter et al., [30]; Takamatsu et al.,1997; Takamatsu et al.,[29]; Lennernas et al [26]; Lennernas et al,1995;
b. Fagerholm et al.,[24]; Kim et al., [21].
c. Zhu et al.,[31]; Bermajo et al.,2003.
Determined in this study
Table 4: The mean Peff values of the drugs, the mean apparent absorption rate constant (Ka) calculated in this study and the corresponding percentage of drug absorbed in humans (FA) are summarized.
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