Phase I: Parameters Group 1 Group  2 Group 3 Group 4 RBC (millions/cumm) 7.05 ± 0.52 4.42 ± ** 7.3 ± NS 11.3 ± *** HB (g%) 13.13 ± 6.65 ± 0.51 *** 10.2 ± * 17.6 ± *** PCV (%) 43.08 ± 27.33 ± 1.80  *** 37.83 ±2.15  NS 58.50 ±2.36 ** MCV (fl) 60.92 ± 61.78 ± 1.27 NS 51.80 ±2.56 * 54.76 ± 1.02 NS MCH (pg) 16.95 ± 0.69 13.81 ± 0.19 ** 14.15 ± 0.76 ** 16.61 ± 0.32 NS MCHC (g/dl) 28.62 ± 21.27 ± 0.81 *** 27.37 ± 0.88 NS 35.82 ± 0.70 *

Phase II: Parameters Group 1 Group  2 Group 3a Group 3b Group 4 RBC (millions/cumm) 7.58 ± 0.46 3.87 ± *** 4.48 ± 0.32 ** 6.53 ± NS 12.3 ± *** Hb (g%) 12.63 ± 6.08 ± 0.38 *** 5.96 ± *** 10.85 ± NS 18.6 ± *** PCV (%) 46.00 ± 24.33 ± 1.49  *** 27.50 ±1.17 *** 35.17 ±1.35 ** 56.27 ±2.15 ** MCV (fl) 57.92 ± 62.09 ± 1.79 NS 62.16 ± 2.37 NS 54.47 ± 2.43 NS 52.39 ± 1.92 NS MCH (pg) 17.45 ± 0.69 12.97 ± 0.24 ** 13.52 ± 0.72 *** 15.18 ± 0.45 * 24.31 ± 0.52 ** MCHC (g/dl) 29.85 ± 22.33 ± 0.67 *** 21.73 ± 0.74 *** 34.25 ± 0.88 * 38.12 ± 0.65 **

Table 1: Effect of EPO on CRF induced changes in hematological parameters in both phase I and phase II. Results are expressed as mean ± SEM of 6 animals for each group; * P < 0.05, ** P < 0.01, *** P < 0.001, NS – Not Significant; RBC – Red blood cells, HB – hemoglobin, PCV – packed cell volume, MCV – mean corpuscular volume, MCH – Mean corpuscular hemoglobin, MCHC – Mean corpuscular hemoglobin concentration.

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