Phase I:
Parameters Group 1 Group  2 Group 3 Group 4
OA (sec) 14.39 ± 2.14 6.50 ± 1.05 ** 8.56 ± 1.34 * 12.07 ± 0.91 NS
CA (sec) 55.33 ± 3.73 64.33 ± 5.28 NS 56.33 ± 4.01 NS 49.24 ± 4.15 NS
Centre (sec) 30.28 ± 1.77 29.28 ± 4.27 NS 35.06 ±4.73 NS 37.97 ±3.16 NS
EOA (No.of times) 6.33 ±1.11 2.86 ± 0.16 * 3.50 ± 0.42 NS 5.97 ± 0.8 NS
ECA (No.of times) 4.67 ±0.55 5.67 ±0.33 NS 6.33 ± 0.66 NS 5.50 ± 0.56 NS
SAP (No.of times) 4.17 ±0.66 8.13 ± 1.15 ** 5.00 ± 0.57 NS 7.83 ± 0.61 **
Rearing (No.of times) 16.73 ± 1.04 29.83 ± 1.24 ** 23.83 ± 1.4 NS 24.17 ± 1.49 NS
Grooming (No.of times) 3.50 ± 0.76 6.15 ±0.51 * 3.83 ±0.6 NS 4.45 ±0.48 NS
Defecation (No.of times) 1.43 ±0.7 3.83 ±0.47 * 2.83 ±0.47 NS 2.50 ±0.42 NS
Head dips (No.of times) 3.67 ±0.55 9.09 ±0.81 *** 6.17 ±0.47 * 4.54 ±0.33 NS
Phase II:
Parameters Group 1 Group  2 Group 3a Group 3b Group 4
OA (sec) 17.19 ± 1.14 5.58 ± 0.95 *** 5.61 ± 1.07 ** 7.22 ± 1.11 ** 11.67 ± 0.79 *
CA (sec) 53.27 ± 3.28 67.69 ± 6.65 NS 65.17 ± 5.21 NS 57.50 ±4.71 NS 45.67 ± 3.47 NS
Centre (sec) 29.51 ± 2.03 28.28 ± 3.95 NS 29.39 ±4.24 NS 35.33 ±4.9 NS 42.67 ±2.68 *
EOA (No.of times) 5.33 ±1.27 3.00 ± 0.36 NS 2.67 ± 0.42 * 3.17 ± 0.87 NS 6.17 ± 0.7 NS
ECA (No.of times) 3.27 ±0.71 6.17 ±0.41 * 5.17 ± 0.3 NS 5.33 ± 0.49 NS 4.13 ± 0.26 NS
SAP (No.of times) 3.67 ±0.45 7.00 ± 1.15 * 9.17 ± 0.6 *** 7.83 ± 0.7 ** 7.33 ± 0.55 **
Rearing (No.of times) 18.23 ± 1.84 31.83 ± 1.08 ** 32.17 ± 2.38 *** 27.83 ± 2.57 * 22.77 ± 1.31 NS
Grooming (No.of times) 2.87 ± 0.17 5.45 ±0.44 * 5.00 ± 0.57 NS 5.33 ±0.49 NS 3.50 ±0.61 NS
Defecation (No.of times) 1.83 ±0.3 4.26 ±0.67 * 3.50 ±0.42 NS 3.00 ±0.36 NS 4.17 ±0.61 *
Head dips (No.of times) 3.01±0.22 9.17 ±0.94 *** 9.33 ±0.76 *** 7.00 ±0.93 * 4.00 ±0.73 NS
Table 2: Effect of EPO on CRF induced behavioral changes is recorded by using plus maze in both phase I and phase II. Results are expressed as mean ± SEM of 6 animals for each group; * P < 0.05, ** P < 0.01, *** P < 0.001, NS – Not Significant; OA- Time spent in open arm, CA- Time spent in closed arm, centre – Time spent in the centre, EOA – Number of entry in open arm, ECA – Number of entries in closed arm, SAP – Stretch attending posture.
Goto home»