| Losartan |
| Variable |
Unit |
N |
Mean |
SD |
Min |
Median |
Max |
CV% |
| AUC % extrap |
(%) |
21 |
2.46 |
0.98 |
1.07 |
2.06 |
5.15 |
39.77 |
| AUC0-8h |
([ng*hr]/mL) |
21 |
361.55 |
105.08 |
223.79 |
378.30 |
630.95 |
29.06 |
| AUCinf |
([ng*hr]/mL) |
21 |
382.76 |
112.02 |
239.09 |
403.35 |
665.63 |
29.27 |
| ASCLAST |
([ng*hr]/mL) |
21 |
373.67 |
110.66 |
231.19 |
395.29 |
655.65 |
29.62 |
| CLAST |
(ng/mL) |
21 |
2.94 |
0.64 |
2.00 |
3.00 |
4.10 |
21.89 |
| Cmax |
(ng/mL) |
21 |
211.05 |
100.61 |
106.00 |
192.00 |
481.00 |
47.67 |
| Ke |
(1/hr) |
21 |
0.35 |
0.07 |
0.17 |
0.34 |
0.47 |
21.04 |
| T1/2 |
(hr) |
21 |
2.10 |
0.58 |
1.47 |
2.01 |
4.08 |
27.63 |
| TLAST |
(hr) |
21 |
10.48 |
1.53 |
8.00 |
10.00 |
12.00 |
14.61 |
| Tmax |
(hr) |
21 |
1.03 |
0.71 |
0.50 |
0.75 |
2.67 |
68.81 |
| Vd |
(L) |
21 |
417.54 |
122.19 |
241.92 |
401.76 |
678.22 |
29.27 |
| Cl |
(L/h) |
21 |
141.15 |
39.57 |
75.12 |
123.96 |
209.13 |
28.03 |
| Losartan + Aspirin |
| Variable |
Unit |
N |
Mean |
SD |
Min |
Median |
Max |
CV% |
| AUC % extrap |
(%) |
21 |
2.50 |
1.11 |
1.38 |
2.21 |
5.65 |
44.47 |
| AUCALL |
([ng*hr]/mL) |
21 |
384.89 |
143.63 |
196.96 |
366.12 |
761.11 |
37.32 |
| AUC0-8h |
([ng*hr]/mL) |
21 |
369.63 |
138.50 |
194.56 |
353.02 |
731.21 |
37.47 |
| AUCinf |
([ng*hr]/mL) |
21 |
392.43 |
145.82 |
198.89 |
373.46 |
772.54 |
37.16 |
| ASCLAST |
([ng*hr]/mL) |
21 |
383.30 |
144.41 |
194.56 |
366.12 |
761.11 |
37.67 |
| CLAST |
(ng/mL) |
21 |
3.12 |
0.87 |
2.00 |
2.80 |
5.40 |
27.91 |
| Cmax |
(ng/mL) |
21 |
210.62 |
104.94 |
60.30 |
178.00 |
438.00 |
49.83 |
| Ke |
(1/hr) |
21 |
0.37 |
0.10 |
0.23 |
0.35 |
0.60 |
26.78 |
| T1/2 |
(hr) |
21 |
2.02 |
0.52 |
1.16 |
1.98 |
2.96 |
25.85 |
| TLAST |
(hr) |
21 |
10.57 |
1.69 |
8.00 |
12.00 |
12.00 |
15.99 |
| Tmax |
(hr) |
21 |
1.13 |
0.67 |
0.50 |
0.75 |
2.67 |
59.35 |
| Vd |
(L) |
21 |
405.08 |
142.11 |
204.93 |
364.93 |
742.51 |
35.08 |
| Cl |
(L/h) |
21 |
144.72 |
52.76 |
64.72 |
133.88 |
251.40 |
36.46 |
|
