Comparison of the geometric

	*Paracetamol*		*Ibuprofen*
	*Maxigesic®*	*Monotherapy*	*Maxigesic®*	*Monotherapy*
C_max (µg·mL^-1)	13.89	14.87	21.48	22.08
Geometric mean ratio [%], (90% CI)	95.77 (81.62, 112.37)^b		97.23 (85.28, 110.85)^b
AUC_0-t (µg·mL^-1·h)	38.32	36.51	80.12	78.56
Geometric mean ratio [%], (90% CI)	103.86 (100.16, 107.71)^b		101.18 (95.72, 106.97)^b
AUC_0-inf (µg·mL^-1·h)	40.47	38.42	82.30	80.84
Geometric mean ratio [%], (90% CI)	104.08 (100.15, 108.15)^b		101.07 (96.01, 106.41)^b
T_max (minutes)^a	30	38	90	60
T_1/2 (h)	3.14	3.11	2.12	2.29

^amedian ^bwithin bioequivalence limits (80%-125%)

Table 2: Comparison of the geometric mean (unless stated otherwise) pharmacokinetic parameters of paracetamol and ibuprofen after administration as monotherapy or fixed-dose combination, Maxigesic® in the fasted state.

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