Tmax (minutes) n Paracetamol Ibuprofen Combination - fasted Monotherapy -fasted Combination - fasted Monotherapy -fasted FDC 300/1000 (Maxigesic®) 26 30 38 90 60 Median difference (95% CI)   -6.4 (-22, 15) 22.5 (-22, 60) FDC 400/650a (mean [SD]) 20 48 (24) 54 (30) 84 (42) 84 (42) FDC 400/1000 25 30 40 75 75 Median difference (95% CI)   -15 (-30, 0) 7.5 (-15, 37.5)     Combination- fed Combination - fasted Combination - fed Combination - fasted FDC 300/1000 (Maxigesic®) 26 53 30 53 90 Median difference (95% CI) 22.5 (0, 60) -22.5 (-45, 0) FDC 400/1000 25 90 30 120 75 Median difference (95% CI) 55 (30, 80) 25 (0, 45)

ano fast-fed comparison has been published for FDC 400/650

Table 4: Tmax for ibuprofen and paracetamol after single dose administration of fixed dose combinations: 300/1000 (Maxigesic®), 400/650 and 400/1000.

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