| (AUCexo)test / (AUCexo)ref |
AUCendo /AUCtot |
| 0.05 |
0.1 |
0.2 |
0.3 |
0.5 |
| 0.75 |
0.76 |
0.78 |
0.8* |
0.83* |
0.88* |
| 0.8 |
0.81 |
0.82 |
0.84 |
0.86 |
0.9 |
| 1.25 |
1.24 |
1.23 |
1.2 |
1.18 |
1.13 |
| 1.3 |
1.29 |
1.27 |
1.24* |
1.21* |
1.15* |
| 1.5 |
1.48 |
1.45 |
1.4 |
1.35 |
1.25* |
(AUCtot)test, Total (endogenous + exogenous) AUC for test article; (AUCtot)ref ,
Total AUC for reference; (AUCexo)test, AUC for exogenous test article; (AUCexo)ref AUC for exogenous reference; AUCendo, endogenous AUC; AUCtot, total
(endogenous + exogenous) AUC
* indicates ratios of (AUCtot)test/(AUCtot)ref which meet BE criteria when total
AUC ratio is used but do not meet BE criteria when exogenous AUC ratio is
used. |
