Therapeutic Class Drugs Anticancer drugs Actinomycin D, docetaxel, doxorubicin, etoposide, imatinib, paclitaxel, vinblastine, vincristine Antidepressants Amitriptyline, nortriptyline Steroids Dexamethasone, methylprednisolone Immunosuppressants Cyclosporin A, sirolimus, tacrolimus HIV protease inhibitors Amprenavir, indinavir, nelfinavir, saquinavir, ritonavir Antibiotics Erythromycin, levofloxacin, ofloxacin, sparfloxacin Antifungal agents Itraconazole ß-blockers Bunitrolol, carvedilol, celiprolol, talinolol Ca2+ channel drugs Verapamil, diltiazem Cardiac drugs Digoxin, digitoxin, quinidine HMG-CoA inhibitors Artovastatin, lovastatin H1-antihistamines Fexofenadine, terfenadine H2-antihistamines Cimetidine, ranitidine

Table 1: Examples of drugs that are substrates of P-gp efflux transporter [18,19].

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