|
|
VEGF expression |
|
COX-2 expression |
|
|
|
Positive |
Negative |
|
Positive |
Negative |
|
Characteristics |
Cases |
n (%) |
n (%) |
P |
n (%) |
n (%) |
P |
Gender |
|
|
|
0.249 |
|
|
0.992 |
Female |
47 |
26(55.3) |
21(44.7) |
|
29(61.7) |
18(38.3) |
|
Male |
191 |
123(64.4) |
68(35.6) |
|
118(61.8) |
73(38.2) |
|
Age（years） |
|
|
|
0.124 |
|
|
0.509 |
<55 |
47 |
34(72.3) |
13(27.7) |
|
31(66.0) |
16(34.0) |
|
≥55 |
191 |
115(60.2) |
76(39.8) |
|
116(60.7) |
75(39.3) |
|
Tumor location |
|
|
|
0.679 |
|
|
0.309 |
Cardia |
121 |
76(62.8) |
45(37.2) |
|
77(63.6) |
44(36.4) |
|
Corpus |
49 |
33(67.3) |
16(32.7) |
|
33(67.3) |
16(32.7) |
|
Antrum |
58 |
33(56.9) |
25(43.1) |
|
30(51.7) |
28(48.3) |
|
Whole Stomach |
10 |
7(70.0) |
3(30.0) |
|
7(70.0) |
3(30.0) |
|
Tumor size |
|
|
|
0.013 |
|
|
0.050 |
<5 cm |
109 |
59(54.1) |
50(45.9) |
|
87(67.4) |
42(32.6) |
|
≥5 cm |
129 |
90(69.8) |
39(30.2) |
|
60(55.0) |
49(45.0) |
|
Histological type |
|
|
|
0.722 |
|
|
0.004 |
Tubular or Papillary |
212 |
132(62.3) |
80(37.7) |
|
131(61.8) |
81(38.2) |
|
Mucinous |
19 |
12(63.2) |
7(36.8) |
|
16(84.2) |
3(15.8) |
|
Squamous cell |
3 |
3(100.0) |
0(0.0) |
|
0(0.0) |
3(100.0) |
|
Adenosquamous |
2 |
1(50.0) |
1(50.0) |
|
0(0.0) |
2(100.0) |
|
Neuroendocrine |
2 |
1(50.0) |
1(50.0) |
|
0(0.0) |
2(100.0) |
|
Differentiation |
|
|
|
0.610 |
|
|
0.121 |
Well+Intermediate |
134 |
82(61.2) |
52(38.8) |
|
77(57.5) |
57(42.5) |
|
Poorly |
104 |
67(64.4) |
37(35.6) |
|
70(67.3) |
34(32.7) |
|
Serosa invasion |
|
|
|
0.023 |
|
|
0.001 |
No |
58 |
29(50.0) |
29(50.0) |
|
25(43.1) |
33(56.9) |
|
Yes |
180 |
120(66.7) |
60(33.3) |
|
122(67.8) |
58(32.3) |
|
Clinical stage |
|
|
|
0.001 |
|
|
0.195 |
Early |
17 |
4(23.5) |
13(76.5) |
|
8(47.1) |
9(52.9) |
|
Advanced |
221 |
145(65.6) |
76(34.4) |
|
139(62.9) |
82(37.1) |
|
TNM stage |
|
|
|
0.014 |
|
|
0.000 |
I+II |
104 |
56(53.8) |
48(46.2) |
|
51(49.0) |
53(51.0) |
|
III+IV |
134 |
93(69.4) |
41(30.6) |
|
96(71.6) |
38(28.4) |
|
Lymph node metastasis |
|
|
|
0.014 |
|
|
0.002 |
No |
86 |
45(52.3) |
41(47.7) |
|
42(48.8) |
44(51.2) |
|
Yes |
152 |
104(68.4) |
48(31.6) |
|
105(69.1) |
47(30.9) |
|
COX-2 expression |
|
|
|
0.006 |
|
|
- |
Positive n (%) |
147 |
102(69.4) |
45(30.6) |
|
- |
- |
|
Negative n (%) |
91 |
47(51.6) |
44(48.4) |
|
- |
- |
|
Family history |
|
|
|
0.311 |
|
|
0.989 |
No |
217 |
138(63.6) |
79(36.4) |
|
134(61.8) |
83(38.2) |
|
Yes |
21 |
11(52.4) |
10(47.6) |
|
13(61.9) |
8(38.1) |
|
Smoking |
|
|
|
0.403 |
|
|
0.099 |
No or occasionally |
112 |
67(59.8) |
45(40.2) |
|
63(56.3) |
49(43.8) |
|
Yes |
126 |
82(65.1) |
44(34.9) |
|
84(66.7) |
42(33.3) |
|
Alcohol drinking |
|
|
|
0.421 |
|
|
0.185 |
No or occasionally |
123 |
74(60.2) |
49(39.8) |
|
71(57.7) |
52(42.3) |
|
Yes |
115 |
75(65.2) |
40(34.8) |
|
76(66.1) |
39(33.9) |
|
Pickled or salted food |
|
|
|
0.180 |
|
|
0.289 |
No or occasionally |
123 |
72(58.5) |
51(41.5) |
|
72(58.5) |
51(41.5) |
|
Yes |
115 |
77(67.0) |
38(33.0) |
|
75(65.2) |
40(34.8) |
|
P, Two-sided χ2 test |
