 |
| ap<0.05 as compared with control group (ANOVA and t–Student–Neuman–
Keuls as post hoc test). bp<0.05 as compared with P400 group (ANOVA and t–Student–Neuman–Keuls as post hoc test). cp<0.05 as compared with CRY 0.5 plus P400 (ANOVA and t–Student– Neuman–Keuls as post hoc test). dp<0.05 as compared with CRY 0.5 (ANOVA and t–Student–Neuman–Keuls as post hoc test). ep<0.05 as compared with CRY 1.0 plus P400 (ANOVA and t–Student– Neuman–Keuls as post hoc test). |
| Figure 1: Effects of the crysophanol (0.5 e 1.0 mg/kg) on lipid peroxidation levels and catalase activities in hippocampus of adult mice after status epilepticus induced by pilocarpine. Male mice (25–30 g, 2 months old) were treated with a single dose of pilocarpine (400 mg/kg, intraperitoneal, i.p., n = 6, P400 group); CRY 0.5 or CRY 1.0 group with crysofanol (0.5 mg/kg, i.p., n = 6, CRY 0.5 group); CRY 1.0 group with crysofanol (1.0 mg/kg, i.p., n = 6, CRY 1.0 group) and the control animals with 0.9% saline (i.p., n = 9, Control). The CRY 0.5 plus pilocarpine group was treated with crysonafol (0.5 mg/kg, i.p.) for 30 min prior to pilocarpine injection (400 mg/kg, i.p., n = 6, CRY 0.5 plus P400) and CRY 1.0 plus pilocarpine group was treated with crysonafol (1.0 mg/kg, i.p.) for 30 min prior to pilocarpine injection (400 mg/kg, i.p., n = 6, CRY 1.0 plus P400). Results are expressed as means ± S.E.M. for the number of animals shown inside in parenthesis. Differences in experimental groups were determined by two-tailed analysis of variance (ANOVA) and t–Student–Neuman–Keuls as post hoc test. |
