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| Table 1: Effect of pretreatment with crysophanol (CRY) on pilocarpineinduced seizures and lethality in adult rats. Male mice (25-30 g, 2 months old) were treated with a single dose of pilocarpine (400 mg/kg, intraperitoneal, i.p., n = 6, P400 group); CRY 0.5 or CRY 1.0 group with crysophanol (0.5 mg/kg, i.p., n = 6, CRY 0.5 group); CRY 1.0 group with crysophanol (1.0 mg/kg, i.p., n = 6, CRY 1.0 group) and the control animals with 0.9% saline (i.p., n = 9, Control). The CRY 0.5 plus pilocarpine group was treated with crysophanol (0.5 mg/kg, i.p.) for 30 min prior to pilocarpine injection (400 mg/kg, i.p., n = 6, CRY 0.5 plus P400) and CRY 1.0 plus pilocarpine group was treated with crysophanol (1.0 mg/kg, i.p.) for 30 min prior to pilocarpine injection (400 mg/kg, i.p., n = 6, CRY 1.0 plus P400). Results for latency to first seizure are expressed as means ± SEM of the number of experiments shown in the table. Result for % seizures and % survival are expressed as percentages of the number of animals from each experimental group. ap<0.05 as compared with pilocarpine group (χ2 test); bp<0.05 as compared with CRY 0.5 (χ2 test); cp<0.0001 as compared with P400 group (ANOVA and t-Student-Newman-Keuls test); dp<0.0001 as compared with CRY 0.5 (ANOVA and t-Student-Newman-Keuls test). |
