A. Control, ×20; B. MSG, ×20; C. MSG+NSCs, ×20; D. MSG+FNSCL, ×20. Arrows: a. degeneration and necrosis of neurons; b. intracellular edema and hyperplasia.
|
| Figure 5: Effects of intracerebroventricular transplantation of NSCs and
intracerebroventricular injection of FNSCL on MSG-induced histological
lesions. Sections through hippocampal regions of the mice treated with or
without MSG (MSG+NSCs, MSG+FNSCL) showing morphological effects
of MSG and brain repair following glutamate-induced excitotoxic neuronal
injury mediated by intracerebroventricular transplantation of NSCs or
injection of FNSCL in adult mice. On day 1 and day 10 after the 10-day MSG
exposure (2.0 g/kg per day, ig), the animals in MSG+NSCs group received
intracerebroventricular transplantation and the animals in MSG+FNSCL
group received intracerebroventricular injection of FNSCL respectively. The
histopathology of the animal hippocampi was studied on day 2 after the last
NSC transplantation or injection of FNSCL.
A. Control, ×20; B. MSG, ×20; C. MSG+NSCs, ×20; D. MSG+FNSCL, ×20. Arrows: a. degeneration and necrosis of neurons; b. intracellular edema and hyperplasia. |
