| Characteristic |
FOLFIRI |
FOLFOXIRI |
P (Grade3/4) |
| No. |
% |
No. |
% |
Nausea
Grade1/2
Grade3/4 |
24
1 |
80
3.33 |
28
2 |
93.3
6.7 |
NS |
Vomiting
Grade1/2
Grade 3/4 |
16
1 |
53.33
3.33 |
20
2 |
66.66
6.66 |
NS |
Diarrhea
Grade 1/2
Grade ¾ |
13
6 |
43.33
20 |
16
9 |
53.2
30 |
NS |
Stomatitis
Grade1/2
Grade ¾ |
16
2 |
53.33
6.66 |
24
4 |
80
13.33 |
NS |
Neurotoxicity
Grade1/2
Grade ¾ |
0
0 |
0
0 |
18
6 |
60
20 |
< 0.0001 |
| Toxicity (NCI-CTC grade) |
Asthenia
Grade1/2
Grade3/4 |
16
2 |
53.33
6.66 |
25
3 |
83.33
10 |
NS |
Thrombocytopenia
Grade1/2
Grade3/4 |
6
1 |
20
3.33 |
14
2 |
46.66
6.66 |
NS |
Anemia
Grade1/2
Grade3/4 |
16
1 |
53.33
3.33 |
26
3 |
86.66
10 |
NS |
Neutropenia
Grade1/2
Grade3/4 |
11
8 |
36.66
26.66 |
14
16 |
46.66
53.4 |
0.0006 |
| Febrile Neutropenia |
1 |
3.33 |
2 |
6.66 |
NS |
