| Targeted metabolism |
Metabolic targets |
Agents |
References |
| Glycolysis |
GLUT1
HKII
PGAM
PKM2
LDHA
Transketolase
G6PD
MCT1 |
Fasentin: WZB117: Diclofenac
2-deoxyglucose: 3-bromopyruvate: lonidamine: metformin: cerulenin
MJE3
TLN-232 (or CAP-232)
FX11: Diclofenac
Oxythiamine
6-Aminonicotinamide (6-AN)
Diclofenac |
[52-54]
[18-23]
[50]
[30]
[39-40: 58-59]
[46-47]
[48-49]
[58-59] |
| Glutamine |
Glutaminase
Glutamine
ASCT2 (SLC1A5)
SLC7A5/SLC3A2
|
Compand 968
Phenylacetate
L-γ-glutamyl-p-nitroanilide (GPNA)
2-aminobicyclo-(2:2:1) heptanecarboxylic acid(BCH) |
[3]
[65-66]
[82]
[83] |
| Citric acid Master regulators |
PDK
Mutant IDH
HIF1α
AKT |
Dichloroacetate
Antibody MsMab-1: AGI-5198:
KC7F2: RX-0047
MK-2206 |
[55-57]
[145-146]
[76-77]
[86] |
GLUT1: Glucose Transporter 1; HKII: Hexokinase II; PGAM1: Phosphoglycerate Mutase 1; PKM2: Pyruvate Kinase Muscle Isozyme 2; LDHA: Lactate Dehydrogenase A;
G6PD: Glucose-6-Phosphate Dehydrogenase; MCT1: Monocarboxylate Transporter 1; ASCT2: Solute Carrier Family 1 (Neutral Amino Acid Transporter): Member 5 (also
called SLC1A5); SLC7A5: Solute Carrier Family 7 (Amino Acid Transporter Light Chain: l system): Member 5; SLC3A2: Solute Carrier Family 3 (Amino Acid Transporter
Heavy Chain) member 2; PDK: Pyruvate Dehydrogenase Kinase; IDH: Isocitrate Dehydrogenase; HIF1: Hypoxia Inducible Factor 1; Alpha Subunit (basic helix-loop-helix
transcription factor); AKT: v-akt Murine Thymoma Viral Oncogene Homolog