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Figure 4: (a) The time course of the in vivo experiment.
(b) Representative image of luciferase expression of MSCs 24 hours after the transfection.
(c) In vivo fluorescence images of injected MSCs in colon-cancer mouse model at day1, day6.
(d) In vivo fluorescence images of injected MSCs in colon-cancer mouse model with the administration of anti-human HMGB1 antibody at day1, day 6.
(e) CD90 (MSCs) and HMGB1 was detected in the center of tumor (upper row) and peri-tumor (middle row) as arrows, while CD90 was not detected in the tumor from mice administered the antibody (lower row). Scale bars: 100 μm
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