| Collagens |
Distribution |
Function |
Metabolic disease (s) |
| Type I |
Most common of the collagens,distributed in all tissues, even cartilage. |
Structural components for body, essential for the tensile strength of bone. |
Atherosclerosis[69]; fibrotic diseases in many tissues including liver[11] and adipose[25] etc.; Increased in diabetic nephropathy [70] but decreased in T1DM [71]. |
| Type III |
Dominant collagen type of granulation, muscle and artery wall. |
Crucial for collagen I fibrillogenesis and for normal cardiovascular development. |
Vascular Ehlers-Danlos syndrome[72];Atherosclerosis[69]; fibrotic diseases in many tissues including liver[11] and adipose [25]; Increased in T2DM [73] and T1DM [71] |
| Type IV |
Structural component of basement membrane |
Associated with angiogenesis. |
Increased in diabetic nephropathy [74,75];Rtinopathy[76]; Liver fibrosis [77]. |
| Type V |
Structural component of basement. High expression in muscle, adipose and islet. |
Interact with type I collagen, inhibits endothelial cell adhesion and proliferation. |
Atherosclerosis [48,69]; Glucose homeostasis and diabetes[21]; Liver fibrosis[9]. |
| Type VI |
Dominant structural component of connective tissues like vessels, liver, adipose and muscle. |
Major structural component of microfibrils. |
Atherosclerosis[69]; Metabolic dysregulation and adipose fibrosis[20]; Liver fibrosis[78] and myosclerosis myopathy[79]. |
| Type VIII |
Stuctural component of ECM like sclera and vasculature. |
Stabilization of membranes, angiogenesis and interacts with ECMs |
Atherosclerosis[80]. |
| Type XII |
Structural component of connective tissue e.g. skin. |
Interacts with other matrix components. |
Diabetic retinopathy[81]. |
| Type XIV |
Structural component of connective tissue like blood vessels. |
Interacts with other matrix components. |
Diabetic retinopathy[81]. Liver fibrosis[8] |
| Type XVIII |
Structural component of basement membrane. |
Inhibition angiogenesis and tumor growth. |
Liver fibrosis[82]. |
