| Structurestudied |
Evidences |
Conclusions |
References |
| Fetal lungs of pregnant ewes |
Impaired expression of pulmonary surfactant protein A, as well as decrease in the VEGF expression in the fetal lung |
Alterations in fetallungmaturation and immunity |
Lazic et al. [18,19]
Giliberti et al.,[16] |
| Mouse embryonic and adult lung tissues |
Class I and IV ADH isozymes metabolize ethanol and retinol |
High levels of ethanol inhibit retinol metabolism altering the normal development of epithelial lung tissues |
Ang et al., [20] |
| Foetal lungs from pregnant guinea pig exposed to alcohol and Streptococcus pneumonia |
Deficient alveolar macrophage phagocytosis |
Increase risk of pulmonary infection after birth |
Sozo et al.,[21] |
| Foetal lungs of ethanol exposed pregnant guinea pig |
Impairment in extracellular matrix deposition and surfactant protein gene expression |
Increased risk of respiratory distress syndrome after birth |
Gautier et al., [22] |
| Fetal lung of ethanol exposed pregnant mice |
Weigth decrease and higher expression of Hoxb5 in the saccular phase of lung development |
Alterations on lung development |
Wang et al.,[23] |
