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| Figure 4: Human brain microvascular endothelial cells (HBMEC) and human hepatocellualar carcinoma cells (Huh7) were exposed to the methanolic extract of clinical and non-clinical isolates of Aspergillus flavus and LDH assays were performed to assess cytotoxicity. Note that all isolates tested showed host cell death as compared to control, except C3 and S4 which showed minimal host cell death (P<0.01** using Student’s t-test) (A). The isolates C1, C2, C4 C5 and S2 showed increased cell death as compared to control (P<0.05* and P<0.01** using Student’s t-test) (B). Equal volume of methanol was used as control. The results are presented as the mean ± standard error of three independent experiments performed in duplicate. |
