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Figure 3: BMSCs improved survival after whole-body ionizing irradiation combined with skin wound (CI). B6D2F1/J mice were exposed to γ-radiation followed by 15% TBSA skin-wound trauma.BMSCs (approximately 3 × 106 cells per mouse) were injected via tail vein 24 h after CI. N=10–11 per group and repeated once. (A)9.25 Gy. 30% survival improvement was observed. *P<0.05 vs. CI+DMEM. (B) 9.75 Gy. 20% survival improvement was observed.*P<0.05 vs. CI+DMEM. CI: Radiation + Wound; DMEM:Dulbecco’s Modified Eagle’s Medium. |