Figure 6: Complete clinical and radiographic response following concurrent erlotinib, celecoxib and reirradiation in a patient with recurrent head and neck cancer who failed prior chemoradiation, total laryngectomy and neck dissection. a. Pretreatment CT and PET demonstrated a massive tumor in the oropharyngeal wall, reconstructed pharynx and right cervical lymph node. b. Following combined treatment, the patient had a complete response on CT and PET. The patient remains alive and free of recurrent disease 10 months after treatment. c. Immunohistochemical staining of pretreatment biopsy samples demonstrates focal strong COX-2 positivity and strong EGFR positivity.

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