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| Figure 2: BDNF and GABA Effects and Interactions on Neuroblasts in the RMS. (A) BDNF is promigratory and chemoattractive via TrkB and p75NTR receptors expressed on migrating neuroblasts. (B) (1) Secreted GABA (2) inhibits neuronal migration efficacy (3) in addition to being taken up by astrocytes via GATs resulting in the insertion of TrkBRs on astrocytic membranes that (4) Bind and trap BDNF from interacting with TrkBRs and p75NTRs on neuroblasts, thereby decreasing migration by 2 mechanisms – increased GABA and decreased BDNF. For full explanation and references, see the text (Molecular Factors Influencing Migration through the RMS: GABA and BDNF). |
