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| Figure 3: Summary of Some Effects and Interactions of β1 Integrins, Netrins, and Slits. β1 integrins on migrating neuroblasts associate with extracellular matrix molecules (diagonal light grey bars) to provide “traction” and to enhance migration. Netrins secreted by the OB are promigratory and chemoattractive via DCC and Neogenin receptors expressed on migrating neuroblasts. Netrins also have a chemorepulsive effect from the SVZ, which may be explained by the finding that a DCC/UNC5 receptor complex repels neurons from netrins. It is possible that netrins may selectively express netrin attractive receptors on their leading edge and repulsive receptors on their trailing edge providing pulling and pushing forces, respectively, enhancing migration. Slit repels neurons from the SVZ and from areas outside the RMS. Additionally, Slits have been found to bind directly to Netrins. For full explanation and references, see the text (Molecular Factors Influencing Migration through the RMS: β1 Integrins and Netrins, and Slit Signaling). |
