Figure 1: Slice-based biosensor and the equivalent circuit model. (a) Interface model of the biosensor and the electrolyte, (b) Coupling sketch of the slice and the biosensor (modified from [19]), (c) Measurement principle of the slice-based biosensor. Rs and Rs: electrolyte resistance, CI: interfacial capacitance induced by the electrodes, ZF: faradic impedance, gleak (S/m2): leak conductance along portrait, rsheet(O): sheet resistance along landscape orientation, Cs (F/m2): capacitance of tissue-substrate interface, Rgap: sealing resistance of medium layer in the tissue-substrate gap, Re: electrode impedance caused by electrochemistry.