Genotypes

Cases

 

Controls

 

P†

Crude OR
(95% CI)

Adjusted OR# (95% CI)

P‡

(n=311)

 

(n= 425)

 

n

%

n

%

VEGFrs1547651(A/T)

 

 

 

 

0.228

 

 

 

AA

235

75.6

337

80.0

 

1.00

1.00

 

AT

75

24.1

81

19.2

 

1.33(0.93-1.90)

1.33(0.93-1.90)

0.116

TT

1

0.3

3

0.7

 

0.48(0.05-4.62)

0.49(0.05-4.81)

0.541

AT+TT

76

24.4

84

19.9

 

1.30(0.91-1.85)

1.30(0.92-1.85)

0.142

T allele

0.124

 

0.103

 

0.220

 

 

 

VEGFrs699947(C/A)

 

 

 

 

0.162

 

 

 

CC

166

53.9

212

50.0

 

1.00

1.00

 

AC

119

38.6

190

44.8

 

0.80(0.59-1.09)

0.80(0.59-1.09)

0.152

AA

23

7.5

22

5.2

 

1.34(0.72-2.48)

1.36(0.73-2.53)

0.332

AC+AA

142

46.1

212

50.0

 

0.86(0.64-1.15)

0.86(0.64-1.15)

0.297

A allele

0.268

 

0.276

 

0.732

 

 

 

VEGFrs2010963(G/C)

 

 

 

 

0.972

 

 

 

GG

96

31.4

135

32.1

 

1.00

1.00

 

CG

154

50.3

210

50.0

 

1.03(0.74-1.44)

1.03(0.74-1.44)

0.874

CC

56

18.3

75

17.9

 

1.05(0.68-1.62)

1.04(0.67-1.61)

0.858

CG+CC

210

68.6

285

67.9

 

1.04(0.76-1.42)

1.04(0.76-1.42)

0.825

C allele

0.435

 

0.429

 

0.818

 

 

 

VEGFrs1005230(C/T)

 

 

 

 

0.111

 

 

 

CC

168

54.7

212

50.0

 

1.00

1.00

 

CT

116

37.8

190

44.8

 

0.77(0.57-1.05)

0.77(0.57-1.05)

0.095

TT

23

7.5

22

5.2

 

1.320.71-2.45)

1.34(0.72-2.50)

0.352

CT+TT

139

45.3

212

50.0

 

0.83(0.62-1.11)

0.83(0.61-1.11)

0.206

T allele

0.264

 

0.276

 

0.607

 

 

 

VEGFrs735286(G/A)

 

 

 

 

0.923

 

 

 

GG

94

30.5

135

31.8

 

1.00

1.00

 

AG

161

52.3

216

50.9

 

1.07(0.77-1.49)

1.07(0.76-1.49)

0.704

AA

53

17.2

73

17.2

 

1.04(0.67-1.62

1.02(0.66-1.59)

0.931

AG+AA

214

69.5

289

68.1

 

1.06(0.77-1.46)

1.06(0.77-1.46)

0.708

A allele

0.433

 

0.427

 

0.803

 

 

 

VEGFrs833052(C/A)

 

 

 

 

0.736

 

 

 

CC

135

43.5

192

45.9

 

1.00

1.00

 

AC

147

47.4

186

44.5

 

1.12(0.83-1.53)

1.13(0.83-1.53)

0.454

AA

28

9.0

40

9.6

 

1.00(0.59-1.69)

1.00(0.59-1.70)

0.997

CA+AA

175

56.3

226

54.1

 

1.10(0.82-1.48)

1.10(0.82-1.48)

0.516

A allele

0.327

 

0.318

 

0.709

 

 

 

VEGFrs833068(G/A)

 

 

 

 

0.336

 

 

 

GG

97

31.4

134

31.7

 

1.00

1.00

 

AG

145

46.9

215

50.8

 

0.93(0.67-1.30)

0.93(0.67-1.30)

0.680

AA

67

21.7

74

17.5

 

1.25(0.82-1.91)

1.24(0.81-1.89)

0.318

AG+AA

212

68.6

289

68.3

 

1.01(0.74-1.39)

1.01(0.74-1.39)

0.932

A allele

0.451

 

0.429

 

0.394

 

 

 

VEGFrs833070(G/A)

 

 

 

 

0.057

 

 

 

GG

184

59.5

232

52.7

 

1.00

1.00

 

AG

106

34.3

181

42.8

 

0.71(0.52-0.97)

0.71(0.52-0.96)

0.028

AA

19

6.1

19

4.5

 

1.21(0.62-2.36)

1.22(0.63-2.37)

0.564

AG+AA

125

40.4

200

47.3

 

0.76(0.56-1.02)

0.76(0.56-1.02)

0.064

A allele

0.233

 

0.259

 

0.258

 

 

 

VEGFrs3024994(C/T)

 

 

 

 

0.697

 

 

 

CC

277

90.2

379

89.6

 

1.00

1.00

 

CT

30

9.8

42

9.9

 

1.02(0.63-1.68)

1.02(0.62-1.67)

0.949

TT

0

0

2

0.5

 

 

 

 

CT+TT

30

9.8

44

10.4

 

0.93(0.57-1.52)

0.94(0.57-1.53

0.796

T allele

0.049

 

0.054

 

0.640

 

 

 

VEGFrs3025007(C/T)

 

 

 

 

0.077

 

 

 

CC

164

53.8

198

47.0

 

1.00

1.00

 

CT

110

36.1

187

44.4

 

0.71(0.52-0.97)

0.71(0.52-0.97)

0.034

TT

31

10.2

36

8.6

 

1.04(0.62-1.75)

1.04(0.62-1.76)

0.882

CT+TT

141

46.3

223

53.0

 

0.76(0.57-1.03)

0.76(0.57-1.03)

0.075

T allele

0.282

 

0.308

 

0.291

 

 

 

VEGFrs3025021(C/T)

 

 

 

 

0.102

 

 

 

CC

231

75.2

302

71.4

 

1.00

1.00

 

CT

65

21.2

113

26.7

 

0.75(0.53-1.07)

0.75(0.53-1.07)

0.111

TT

11

3.6

8

1.9

 

1.80(0.71-4.54)

1.84(0.73-4.67)

0.197

CT+TT

76

24.8

121

28.6

 

0.82(0.59-1.15)

0.82(0.59-1.15)

0.252

T allele

0.142

 

0.152

 

0.567

 

 

 

VEGFrs3025030(G/C)

 

 

 

 

0.143

 

 

 

GG

200

65.6

259

62.9

 

1.00

1.00

 

CG

92

30.2

144

35.0

 

0.83(0.60-1.14)

0.83(0.60-1.14)

0.254

CC

13

4.3

9

2.2

 

1.87(0.78-4.46)

1.92(0.80-4.59)

0.144

CG+CC

105

34.5

153

37.2

 

0.89(0.65-1.21)

0.89(0.65-1.22)

0.468

C allele

0.193

 

0.197

 

0.881

 

 

 

VEGFrs3025035(C/T)

 

 

 

 

0.555

 

 

 

CC

203

65.9

290

68.4

 

1.00

1.00

 

CT

94

30.5

124

29.2

 

1.08(0.78-1.50)

1.08(0.79-1.50)

0.623

TT

11

3.6

10

2.4

 

1.57(0.66-3.77)

1.56(0.65-3.76)

0.320

CT+TT

105

34.1

134

31.6

 

0.89(0.65-1.22)

1.12(0.82-1.53)

0.470

T allele

0.188

 

0.170

 

0.360

 

 

 

VEGFrs3025039(C/T)

 

 

 

 

0.064

 

 

 

CC

206

68.4

276

66.8

 

1.00

1.00

 

CT

83

27.6

131

31.7

 

0.85(0.61-1.18)

0.86(0.62-1.19)

0.364

TT

12

4.0

6

1.5

 

2.68(0.99-7.26)

2.61(0.96-7.10)

0.060

CT+TT

95

31.6

137

33.2

 

0.93(0.68-1.28)

0.94(0.68-1.29)

0.693

T allele

0.178

 

0.173

 

0.821

 

 

 


# Adjusted for age and gender in a logistic regression model.
Two-sided ?2 test for either genotype distribution or allele frequency.
Two-sided ?2 test for difference in frequency distribution of genotype between cases and controls by adjusted for age and gender.
Table 1: Genotype frequencies of VEGF polymorphisms in the GC cases and the controls.