VEGF expression

 

COX-2 expression

 

 

 

Positive

Negative

 

Positive

Negative

 

Characteristics

Cases

n (%)

n (%)

P

n (%)

n (%)

P

Gender

 

 

 

0.249

 

 

0.992

Female

47

26(55.3)

21(44.7)

 

29(61.7)

18(38.3)

 

Male

191

123(64.4)

68(35.6)

 

118(61.8)

73(38.2)

 

Age(years)

 

 

 

0.124

 

 

0.509

<55

47

34(72.3)

13(27.7)

 

31(66.0)

16(34.0)

 

≥55

191

115(60.2)

76(39.8)

 

116(60.7)

75(39.3)

 

Tumor location

 

 

 

0.679

 

 

0.309

Cardia

121

76(62.8)

45(37.2)

 

77(63.6)

44(36.4)

 

Corpus

49

33(67.3)

16(32.7)

 

33(67.3)

16(32.7)

 

Antrum

58

33(56.9)

25(43.1)

 

30(51.7)

28(48.3)

 

Whole Stomach

10

7(70.0)

3(30.0)

 

7(70.0)

3(30.0)

 

Tumor size

 

 

 

0.013

 

 

0.050

<5 cm

109

59(54.1)

50(45.9)

 

87(67.4)

42(32.6)

 

≥5 cm

129

90(69.8)

39(30.2)

 

60(55.0)

49(45.0)

 

Histological type

 

 

 

0.722

 

 

0.004

Tubular or Papillary

212

132(62.3)

80(37.7)

 

131(61.8)

81(38.2)

 

Mucinous

19

12(63.2)

7(36.8)

 

16(84.2)

3(15.8)

 

Squamous cell

3

3(100.0)

0(0.0)

 

0(0.0)

3(100.0)

 

Adenosquamous

2

1(50.0)

1(50.0)

 

0(0.0)

2(100.0)

 

Neuroendocrine

2

1(50.0)

1(50.0)

 

0(0.0)

2(100.0)

 

Differentiation

 

 

 

0.610

 

 

0.121

Well+Intermediate

134

82(61.2)

52(38.8)

 

77(57.5)

57(42.5)

 

Poorly

104

67(64.4)

37(35.6)

 

70(67.3)

34(32.7)

 

Serosa invasion

 

 

 

0.023

 

 

0.001

No

58

29(50.0)

29(50.0)

 

25(43.1)

33(56.9)

 

Yes

180

120(66.7)

60(33.3)

 

122(67.8)

58(32.3)

 

Clinical stage

 

 

 

0.001

 

 

0.195

Early

17

4(23.5)

13(76.5)

 

8(47.1)

9(52.9)

 

Advanced

221

145(65.6)

76(34.4)

 

139(62.9)

82(37.1)

 

TNM stage

 

 

 

0.014

 

 

0.000

I+II

104

56(53.8)

48(46.2)

 

51(49.0)

53(51.0)

 

III+IV

134

93(69.4)

41(30.6)

 

96(71.6)

38(28.4)

 

Lymph node metastasis

 

 

 

0.014

 

 

0.002

No

86

45(52.3)

41(47.7)

 

42(48.8)

44(51.2)

 

Yes

152

104(68.4)

48(31.6)

 

105(69.1)

47(30.9)

 

COX-2 expression

 

 

 

0.006

 

 

-

Positive n (%)

147

102(69.4)

45(30.6)

 

-

-

 

Negative n (%)

91

47(51.6)

44(48.4)

 

-

-

 

Family history

 

 

 

0.311

 

 

0.989

No

217

138(63.6)

79(36.4)

 

134(61.8)

83(38.2)

 

Yes

21

11(52.4)

10(47.6)

 

13(61.9)

8(38.1)

 

Smoking

 

 

 

0.403

 

 

0.099

No or occasionally

112

67(59.8)

45(40.2)

 

63(56.3)

49(43.8)

 

Yes

126

82(65.1)

44(34.9)

 

84(66.7)

42(33.3)

 

Alcohol drinking

 

 

 

0.421

 

 

0.185

No or occasionally

123

74(60.2)

49(39.8)

 

71(57.7)

52(42.3)

 

Yes

115

75(65.2)

40(34.8)

 

76(66.1)

39(33.9)

 

Pickled or salted food

 

 

 

0.180

 

 

0.289

No or occasionally

123

72(58.5)

51(41.5)

 

72(58.5)

51(41.5)

 

Yes

115

77(67.0)

38(33.0)

 

75(65.2)

40(34.8)

 


P, Two-sided χ2 test

Table 4: Correlation of VEGF expressions with clinicopathological characteristics of GC.