| |
naloxone |
6βNTX |
| Dose |
0.05 mg |
0.0 mg |
0.05 mg |
0.15 mg |
0.5 mg |
1.0 mg |
Withdrawal Scales
OOWS (total) |
2.5 ± 0.6 |
0.7 ± 0.6 |
0.8 ± 0.5 |
1.5 ± 0.6 |
3.5 ± 1.3 |
5.3 ± 4.0* |
| SOWS (total) |
3.0 ± 2.8 |
1.3 ± 1.5 |
0.8 ± 1.0 |
1.3 ± 1.9 |
4.3 ± 2.2 |
4.3 ± 2.8 |
VAS
Any Drug Effect |
15.4 ± 23.7 |
2.0 ± 1.7 |
0.5 ± 1.0 |
1.5 ± 1.7 |
34.3 ± 15.7* |
24.0 ± 21.7* |
| Bad Drug Effect |
13.5 ± 25.0 |
1.3 ± 1.2 |
0.8 ± 1.5 |
17.9 ± 32.5 |
42.5 ± 23.7 |
26.9 ± 33.0 |
| Good Drug Effect |
10.4 ± 18.9 |
1.3 ± 1.2 |
0.3 ± 0.5 |
2.2 ± 2.8 |
6.5 ± 12.3 |
1.0 ± 0.0 |
| Opioid Withdrawal |
5.6 ± 8.2 |
1.7 ± 1.5 |
1.3 ± 2.5 |
1.4 ± 1.3 |
21.0 ± 29.7 |
13.1 ± 8.1 |
| Sickness |
4.6 ± 6.5 |
0.7 ± 0.6 |
0.50 ± 1.00 |
9.3 ± 17.2 |
15.8 ± 18.1 |
9.0 ± 5.6 |
Vital Signs
Systolic BP (mmHg) |
114.0 ± 1.8 |
121.7 ± 2.9 |
121.3 ± 7.0 |
118.5 ± 10.0 |
118.8 ± 7.6 |
134.7 ± 26.4 |
| Diastolic BP (mmHg) |
76.5 ± 3.8 |
83.7 ± 4.9 |
83.0 ± 5.9 |
76.5 ± 5.1 |
80.3 ± 5.7 |
88.3 ± 12.7 |
| Heart Rate (bpm) |
63.5 ± 8.0 |
65.0 ± 4.4 |
61.8 ± 6.2 |
59.5 ± 2.9 |
61.8 ± 5.7 |
71.7 ± 4.9 |
mean ± standard deviation; *p <.05 vs. placebo |
