naloxone

6βNTX

Dose

0.05 mg

0.0 mg

0.05 mg

0.15 mg

0.5 mg

1.0 mg

Withdrawal Scales
OOWS (total)

2.5 ± 0.6

0.7 ± 0.6

0.8 ± 0.5

1.5 ± 0.6

3.5 ± 1.3

5.3 ± 4.0*

SOWS (total)

3.0 ± 2.8

1.3 ± 1.5

0.8 ± 1.0

1.3 ± 1.9

4.3 ± 2.2

4.3 ± 2.8

VAS
Any Drug Effect

15.4 ± 23.7

2.0 ± 1.7

0.5 ± 1.0

1.5 ± 1.7

34.3 ± 15.7*

24.0 ± 21.7*

Bad Drug Effect

13.5 ± 25.0

1.3 ± 1.2

0.8 ± 1.5

17.9 ± 32.5

42.5 ± 23.7

26.9 ± 33.0

Good Drug Effect

10.4 ± 18.9

1.3 ± 1.2

0.3 ± 0.5

2.2 ± 2.8

6.5 ± 12.3

1.0 ± 0.0

Opioid Withdrawal

5.6 ± 8.2

1.7 ± 1.5

1.3 ± 2.5

1.4 ± 1.3

21.0 ± 29.7

13.1 ± 8.1

Sickness

4.6 ± 6.5

0.7 ± 0.6

0.50 ± 1.00

9.3 ± 17.2

15.8 ± 18.1

9.0 ± 5.6

Vital Signs
Systolic BP (mmHg)

114.0 ± 1.8

121.7 ± 2.9

121.3 ± 7.0

118.5 ± 10.0

118.8 ± 7.6

134.7 ± 26.4

Diastolic BP (mmHg)

76.5 ± 3.8

83.7 ± 4.9

83.0 ± 5.9

76.5 ± 5.1

80.3 ± 5.7

88.3 ± 12.7

Heart Rate (bpm)

63.5 ± 8.0

65.0 ± 4.4

61.8 ± 6.2

59.5 ± 2.9

61.8 ± 5.7

71.7 ± 4.9

mean ± standard deviation; *p <.05 vs. placebo
Table 2: Peak values on withdrawal scales, VAS items, and vital signs.
Goto home»