Genetic Variant

Personality Domain

Genotype

ANCOVA (covariate: age)

1 1

1 2

2 2

mean

n

SD

mean

n

SD

mean

n

SD

F

p*

CNR1 rs7766029        1 = T               2 = C

Neuroticism

14.5

51

7.4

15.9

86

7.8

14.8

74

7.0

6.6

<0.001

Extraversion

28.5

51

6.7

29.3

86

6.4

28.5

74

6.2

1.4

0.25

Openness

29.8

51

5.8

29.5

86

6.2

30.3

74

6.2

2.1

0.09

Agreeableness

35.5

51

6.0

34.4

86

5.6

34.5

74

4.2

3.0

0.03

Conscientiousness

34.8

51

6.0

34.7

86

6.0

34.8

74

5.6

1.8

0.14

GABRA2 rs9291283        1 = C            2 = T

Neuroticism

15.3

122

8.1

14.9

80

6.6

13.6

11

5.3

6.1

<0.001

Extraversion

28.5

122

6.4

29.2

80

6.6

29.2

11

4.1

1.1

0.34

Openness

29.9

122

6.3

29.7

80

5.7

32.7

11

6.9

3.0

0.03

Agreeableness

34.8

122

5.2

34.6

80

5.6

35.6

11

4.4

2.6

0.06

Conscientiousness

35.1

122

5.7

34.6

80

6.0

33.8

11

7.0

2.2

0.09

GABRA6 rs3219151              1 = T               2 = C

Neuroticism

13.7

75

6.1

15.2

95

7.5

17.2

43

9.0

7.9

<0.0001

Extraversion

28.8

75

6.3

29.1

95

6.2

28.2

43

7.0

1.2

0.31

Openness

28.6

75

6.0

31.0

95

5.7

30.1

43

6.7

4.3

0.01

Agreeableness

34.9

75

5.0

34.2

95

5.0

35.7

43

6.1

3.6

0.02

Conscientiousness

35.5

75

5.2

34.1

95

5.6

35.3

43

7.5

3.0

0.03

MAMDC1 rs7151262         1 = G               2 = C

Neuroticism

15.1

87

7.9

14.6

85

7.2

16.1

41

7.0

6.0

<0.001

Extraversion

28.9

87

6.4

28.3

85

6.0

29.5

41

7.1

1.2

0.30

Openness

30.1

87

5.7

29.5

85

6.0

30.6

41

7.1

2.1

0.10

Agreeableness

35.4

87

5.4

34.5

85

5.3

34.0

41

5.0

3.3

0.02

Conscientiousness

35.4

87

6.3

35.0

85

5.5

33.4

41

5.7

3.0

0.03


*The significance level was set to p=0.0025 after a Bonferroni correction for multiple testing (0.05/ 20 tests)

Table 1: Association analysis between CNR1, GABRA2, GABRA6 and MAMDC1 polymorphisms with the five personality domains assessed by the NEO-FFI scale, using age as covariate (ANCOVA)