Figure 1: Percent reductions in dorsal striatal dopamine concentrations (pg of dopamine/mg of tissue weight as analyzed with HPLC-EC) versus respective vehicle-treated controls (•—•) and changes in body weights (gm) calculated as differences between weights immediately prior to neurotoxin administration versus that obtained at euthanasia (5-7 days post-neurotoxin) (o----o)-Mean ± SEM. Adult mice (CD-1, Panels A-C; C57/Bl, Panel D) were treated with a single ip injection of methamphetamine at 40 mg/kg (panels A-C) or 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) at 10 mg/kg administered ip at 2 h intervals×4 (panel D). For all methamphetamine-treated conditions greater amounts of dorsal striatal dopamine depletion (A-males versus females, B-testosterone (TP- 5 μg in sesame oil, sc) versus sesame oil treated controls, C-propranolol (PROP-10 mg/kg in saline, ip) versus prazos in (PRAZ - 2 mg/kg in saline, ip)) are associated with greater reductions in body weights. While a very similar profile of reductions in dorsal striatal dopamine between male and female mice is observed in response to MPTP (•—• panels D versus A), no sex differences in body weights are present to MPTP treatment, unlike that obtained for MA (o----o panels D versus A). With the exception of body weights for females versus males in response to MPTP (panel D), all respective pair wise comparisons (independent group t-tests) represent statistically significant differences (p<0.05). All data presented represent studies that had been approved by the IACUC at the Northeast Ohio Medical University (NEOMED). Data were compiled from the following sources: Panel A [14]; Panel B [13,15]; Panel C [16]; Panel D [21].
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