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Figure 2: Effect of NT69L on nicotine withdrawal signs in alcohol-and air-exposed Wistar rats
Alcohol- and air-exposed rats were injected twice daily for 15 days with nicotine (0.35 mg/kg s.c.). On day 15 the nicotine injections were discontinued and the animals were injected with either NT69L (1 mg/kg i.p.) or saline. Withdrawal signs were recorded 30 min post NT69L or saline injection and depicted as total signs /10 min. (n), number of animals in each group. ** Significantly different from air/N (P<0.001); # significantly different from corresponding NT and pre-nicotine (PN, baseline) groups (P<0.001). Inset shows the withdrawal signs expressed as % change from baseline.
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