Figure 4: Effects of NT69L on extracellular DA levels in NA shell after acute injection of saline, nicotine, alcohol, or the combination of nicotine and alcohol
NT69L (1 mg/kg, i.p.) or saline (i.p.) was injected (injection 1) followed by nicotine (0.5 mg/kg, sc), alcohol (1 g/kg i.p.), the combination of nicotine and alcohol, or saline 40 min later (injection 2) during microdialysis. Results are expressed as percentage (mean ± S.E.M.) increase above baseline (Figure 4a). *P<0.05 vs. corresponding group pretreated with NT69L; #P<0.05 vs. saline/saline group (alcohol-red; nicotine-green; alcohol+nicotine-blue). Average percentage change above baseline is shown in Figure 4b. *P<0.05 vs. corresponding group pretreated with NT69L; #P<0.05 vs. saline/saline group.