Figure 5: Effects of NT69L on extracellular glutamate levels in NA shell after acute injection of saline, nicotine, alcohol, or the combination of nicotine and alcohol Rats were treated as described in figure legend 4 (injection 1=NT69L or saline; injection 2=saline, nicotine, alcohol, or combination of nicotine and alcohol). Results are expressed as percentage (mean ± S.E.M.) increase above baseline (Figure 5a). *P<0.05 vs. corresponding group pretreated with NT69L; #P<0.05 vs. saline/saline group (alcohol-red; nicotine-green; alcohol+nicotineblue). Average percentage change above baseline is shown in Figure 5b. *P<0.05 vs. corresponding group pretreated with NT69L; #P<0.05 vs. saline/ saline group, & significantly different from saline/alcohol and saline/nicotine treatment P<0.05.