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| Figure 3: (A) Effects of PMMA (1 -30 mg/kg) on place conditioning in mice. Three conditioning sessions each for the drug and the saline groups were conducted. On day 7, testing of the conditioning was performed. Conditioning scores (CPP score) represent the time spent in the drug-paired place minus the time spent in the saline-paired place. Each point represents the mean conditioning score with the S.E.M. of 10-14 animals. (B) Effect of pretreatment with dopamine D1 receptor antagonist, SCH23390, dopamine D2 receptor antagonist sulpiride, or 5-HT2 receptor antagonist ketanserin on the PMMAinduced place preference in mice. For the antagonist study, SCH23390 (SCH, 0.03 mg/kg, s.c.), sulpiride (SUL, 50 mg/kg, s.c.) or ketanserin (KET, 0.3 mg/ kg, s.c) was administered 10 min before PMMA (5 mg/kg) treatment during conditioning sessions. Each column represents the mean conditioning score with the S.E.M. of 12-14 animals. (A) **P<0.01 vs. saline (SAL)-treated group. (B) *P<0.05, **P<0.01 vs. vehicle (Veh)-pretreated SAL group. #P<0.05 vs. vehicle (Veh)-pretreated PMMA group. |
