Variable Group Dose        
    placebo caffeine 150 caffeine 300 d-amph 20 effect size, η2ρ
ARCI-PCAG control 3.87 3.62 3.52 3.64  
    (0.82) (0.83) (0.79) (0.71)  
  cocaine 1.95 1.83 2.95 2.43  
    (0.58) (0.68) (0.82) (0.67)  
ARCI-A * control 3.20 3.60 3.80 3.22 0.33
    (0.51) (0.68) (0.59) (0.38)  
  cocaine 3.30 3.39 3.19 3.69  
    (0.51) (0.54) (0.44) (0.45)  
ARCI-BG control 6.00 6.35 6.05 5.83  
    (0.39) (0.56) (0.57) (0.36)  
  cocaine 5.69 5.77 5.07 5.57  
    (0.34) (0.37) (0.61) (0.51)  
ARCI-MGB control 4.09 4.34 5.14 4.04  
    (1.26) (1.31) (1.37) (1.28)  
  cocaine 5.29 5.62 4.31 5.18  
    (1.13) (1.23) (0.96) (1.00)  
ARCI-LSD *** control 1.78 2.43 1.23 1.70 0.32
    (0.44) (0.56) (0.41) (0.41)  
  cocaine 0.89 0.48 1.05 0.98  
    (0.47) (0.49) (0.49) (0.45)  
VAS-depression control 0.10 0.10 0.41 0.10  
    (0.10) (0.10) (0.30) (0.06)  
  cocaine 1.05 0.62 1.96 1.10  
    (0.54) (0.47) (1.12) (0.51)  
VAS-fatigue control 3.85 3.00 3.44 3.60  
    (1.37) (1.48) (1.64) (1.07)  
  cocaine 0.68 0.54 1.69 1.17  
    (0.32) (0.25) (0.71) (0.36)  
VAS-tension control 1.05 1.60 1.62 1.53  
    (0.38) (0.53) (0.60) (0.48)  
  cocaine 1.63 0.96 2.38 1.88  
    (0.62) (0.57) (0.94) (0.61)  
VAS-vigor control 8.25 8.50 9.78 8.28  
    (2.06) (1.92) (1.98) (2.01)  
  cocaine 10.42 10.85 9.27 10.31  
    (1.54) (1.59) (1.60) (1.33)  
VAS-anxious control 10.15 10.45 8.50 11.68  
    (5.31) (5.69) (4.91) (4.62)  
  cocaine 19.64 21.35 25.27 21.71  
    (6.17) (6.01) (7.12) (5.43)  
VAS-elated *, ** control 8.65 9.85 13.65 10.43 0.30, 0.37
    (5.33) (5.32) (6.10) (4.48)  
  cocaine 25.99 32.54 21.65 25.71  
    (6.01) (7.62) (5.68) (6.42)  
DEQ- feel effects control 16.75 20.25 9.45 11.37  
    (7.58) (6.31) (4.97) (4.93)  
  cocaine 17.30 20.73 17.62 18.68  
    (5.80) (5.95) (5.91) (6.08)  
DEQ- like effects control 39.92 35.62 52.17 42.25  
    (6.82) (6.89) (6.95) (5.74)  
  cocaine 37.18 39.94 43.75 32.04  
    (9.74) (10.55) (7.21) (8.63)  
DEQ- high control 10.77 12.17 7.17 7.17  
    (5.23) (5.59) (4.16) (3.95)  
  cocaine 14.35 16.14 15.87 14.64  
    (5.45) (5.67) (5.78) (5.44)  
DEQ- like more control 25.77 25.62 32.92 25.65  
    (7.20) (6.54) (7.01) (6.08)  
  cocaine 25.96 25.68 28.71 26.16  
    (9.18) (8.99) (8.48) (8.69)  
Means (delta-method robust standard errors) for subjective effects measures (ARCI, DEQ, VAS) across placebo, 150 mg caffeine, 300 mg caffeine, and 20 mg d-amphetamine doses. Data are averaged across two time points on each dose day, and shown separately for control and cocaine-dependent groups
*p < .05, dose x time interaction, see text for details
**p < .05, dose x group interaction, see text for details
***p < .05, dose x group x time interaction, see text for details
Table 2: Effects sizes are provided for statistically significant outcomes