| Variable |
Group |
Dose |
|
|
|
|
| |
|
placebo |
caffeine 150 |
caffeine 300 |
d-amph 20 |
effect size, η2ρ |
| ARCI-PCAG |
control |
3.87 |
3.62 |
3.52 |
3.64 |
|
| |
|
(0.82) |
(0.83) |
(0.79) |
(0.71) |
|
| |
cocaine |
1.95 |
1.83 |
2.95 |
2.43 |
|
| |
|
(0.58) |
(0.68) |
(0.82) |
(0.67) |
|
| ARCI-A * |
control |
3.20 |
3.60 |
3.80 |
3.22 |
0.33 |
| |
|
(0.51) |
(0.68) |
(0.59) |
(0.38) |
|
| |
cocaine |
3.30 |
3.39 |
3.19 |
3.69 |
|
| |
|
(0.51) |
(0.54) |
(0.44) |
(0.45) |
|
| ARCI-BG |
control |
6.00 |
6.35 |
6.05 |
5.83 |
|
| |
|
(0.39) |
(0.56) |
(0.57) |
(0.36) |
|
| |
cocaine |
5.69 |
5.77 |
5.07 |
5.57 |
|
| |
|
(0.34) |
(0.37) |
(0.61) |
(0.51) |
|
| ARCI-MGB |
control |
4.09 |
4.34 |
5.14 |
4.04 |
|
| |
|
(1.26) |
(1.31) |
(1.37) |
(1.28) |
|
| |
cocaine |
5.29 |
5.62 |
4.31 |
5.18 |
|
| |
|
(1.13) |
(1.23) |
(0.96) |
(1.00) |
|
| ARCI-LSD *** |
control |
1.78 |
2.43 |
1.23 |
1.70 |
0.32 |
| |
|
(0.44) |
(0.56) |
(0.41) |
(0.41) |
|
| |
cocaine |
0.89 |
0.48 |
1.05 |
0.98 |
|
| |
|
(0.47) |
(0.49) |
(0.49) |
(0.45) |
|
| VAS-depression |
control |
0.10 |
0.10 |
0.41 |
0.10 |
|
| |
|
(0.10) |
(0.10) |
(0.30) |
(0.06) |
|
| |
cocaine |
1.05 |
0.62 |
1.96 |
1.10 |
|
| |
|
(0.54) |
(0.47) |
(1.12) |
(0.51) |
|
| VAS-fatigue |
control |
3.85 |
3.00 |
3.44 |
3.60 |
|
| |
|
(1.37) |
(1.48) |
(1.64) |
(1.07) |
|
| |
cocaine |
0.68 |
0.54 |
1.69 |
1.17 |
|
| |
|
(0.32) |
(0.25) |
(0.71) |
(0.36) |
|
| VAS-tension |
control |
1.05 |
1.60 |
1.62 |
1.53 |
|
| |
|
(0.38) |
(0.53) |
(0.60) |
(0.48) |
|
| |
cocaine |
1.63 |
0.96 |
2.38 |
1.88 |
|
| |
|
(0.62) |
(0.57) |
(0.94) |
(0.61) |
|
| VAS-vigor |
control |
8.25 |
8.50 |
9.78 |
8.28 |
|
| |
|
(2.06) |
(1.92) |
(1.98) |
(2.01) |
|
| |
cocaine |
10.42 |
10.85 |
9.27 |
10.31 |
|
| |
|
(1.54) |
(1.59) |
(1.60) |
(1.33) |
|
| VAS-anxious |
control |
10.15 |
10.45 |
8.50 |
11.68 |
|
| |
|
(5.31) |
(5.69) |
(4.91) |
(4.62) |
|
| |
cocaine |
19.64 |
21.35 |
25.27 |
21.71 |
|
| |
|
(6.17) |
(6.01) |
(7.12) |
(5.43) |
|
| VAS-elated *, ** |
control |
8.65 |
9.85 |
13.65 |
10.43 |
0.30, 0.37 |
| |
|
(5.33) |
(5.32) |
(6.10) |
(4.48) |
|
| |
cocaine |
25.99 |
32.54 |
21.65 |
25.71 |
|
| |
|
(6.01) |
(7.62) |
(5.68) |
(6.42) |
|
| DEQ- feel effects |
control |
16.75 |
20.25 |
9.45 |
11.37 |
|
| |
|
(7.58) |
(6.31) |
(4.97) |
(4.93) |
|
| |
cocaine |
17.30 |
20.73 |
17.62 |
18.68 |
|
| |
|
(5.80) |
(5.95) |
(5.91) |
(6.08) |
|
| DEQ- like effects |
control |
39.92 |
35.62 |
52.17 |
42.25 |
|
| |
|
(6.82) |
(6.89) |
(6.95) |
(5.74) |
|
| |
cocaine |
37.18 |
39.94 |
43.75 |
32.04 |
|
| |
|
(9.74) |
(10.55) |
(7.21) |
(8.63) |
|
| DEQ- high |
control |
10.77 |
12.17 |
7.17 |
7.17 |
|
| |
|
(5.23) |
(5.59) |
(4.16) |
(3.95) |
|
| |
cocaine |
14.35 |
16.14 |
15.87 |
14.64 |
|
| |
|
(5.45) |
(5.67) |
(5.78) |
(5.44) |
|
| DEQ- like more |
control |
25.77 |
25.62 |
32.92 |
25.65 |
|
| |
|
(7.20) |
(6.54) |
(7.01) |
(6.08) |
|
| |
cocaine |
25.96 |
25.68 |
28.71 |
26.16 |
|
| |
|
(9.18) |
(8.99) |
(8.48) |
(8.69) |
|
Means (delta-method robust standard errors) for subjective effects measures
(ARCI, DEQ, VAS) across placebo, 150 mg caffeine, 300 mg caffeine, and 20 mg
d-amphetamine doses. Data are averaged across two time points on each dose
day, and shown separately for control and cocaine-dependent groups
*p < .05, dose x time interaction, see text for details
**p < .05, dose x group interaction, see text for details
***p < .05, dose x group x time interaction, see text for details |
