days from baseline manic relapses per time missing (%)* mean manic relapses per visit unit p t conf 1 conf 2 0 0.18 43.89 0.16±0.24 0.18 -1.35 -0.09 0.02 30 0.18 8.98 0.16±0.24 0.02 -2.27 -0.09 -0.01 60 0.18 2.87 0.16±0.24 0.02 -2.33 -0.09 -0.01 90 0.18 2.49 0.16±0.24 0.02 -2.33 -0.09 -0.01 120 0.18 1.62 0.16±0.24 0.02 -2.41 -0.09 -0.01 150 0.17 1.37 0.16±0.24 0.02 -2.39 -0.09 -0.01 180 0.17 1.37 0.16±0.24 0.02 -2.39 -0.09 -0.01 210 0.17 0.75 0.16±0.24 0.02 -2.34 -0.08 -0.01 240 0.17 0.5 0.16±0.24 0.02 -2.27 -0.08 -0.01 270 0.17 0.37 0.16±0.24 0.02 -2.29 -0.08 -0.01 300 0.17 0.12 0.16±0.24 0.02 -2.32 -0.08 -0.01 330 0.17 0.12 0.16±0.24 0.02 -2.32 -0.08 -0.01 360 0.18 0.12 0.16±0.24 0.02 -2.32 -0.08 -0.01 390 0.18 0.12 0.16±0.24 0.02 -2.32 -0.08 -0.01 420 0.18 0.12 0.16±0.24 0.02 -2.32 -0.08 -0.01 450 0.18 0.12 0.16±0.24 0.02 -2.32 -0.08 -0.01 480 0.18 0.12 0.16±0.24 0.02 -2.32 -0.08 -0.01 510 0.18 0.12 0.16±0.24 0.02 -2.32 -0.08 -0.01 540 0.18 0.12 0.16±0.24 0.02 -2.32 -0.08 -0.01 570 0.18 0.12 0.16±0.24 0.02 -2.32 -0.08 -0.01 600 0.18 0.12 0.16±0.24 0.02 -2.32 -0.08 -0.01 630 0.18 0.12 0.16±0.24 0.02 -2.32 -0.08 -0.01 660 0.18 0.12 0.16±0.24 0.02 -2.32 -0.08 -0.01 690 0.18 0.12 0.16±0.24 0.02 -2.32 -0.08 -0.01 720 0.18 0.12 0.16±0.24 0.02 -2.32 -0.08 -0.01 750 0.17 0.12 0.16±0.24 0.02 -2.32 -0.08 -0.01 780 0.17 0.12 0.16±0.24 0.02 -2.32 -0.08 -0.01 810 0.17 0.12 0.16±0.24 0.02 -2.32 -0.08 -0.01 840 0.17 0.12 0.16±0.24 0.02 -2.32 -0.08 -0.01 870 0.17 0.12 0.16±0.24 0.02 -2.32 -0.08 -0.01 900 0.17 0.12 0.16±0.24 0.02 -2.32 -0.08 -0.01 930 0.17 0 0.16±0.24 0.02 -2.33 -0.08 -0.01 960 0.17 0 0.16±0.24 0.02 -2.33 -0.08 -0.01 990 0.17 0 0.16±0.24 0.02 -2.33 -0.08 -0.01 1020 0.17 0 0.16±0.24 0.02 -2.33 -0.08 -0.01 1050 0.17 0 0.16±0.24 0.02 -2.33 -0.08 -0.01 1080 0.17 0 0.16±0.24 0.02 -2.33 -0.08 -0.01 1110 0.17 0 0.16±0.24 0.02 -2.33 -0.08 -0.01 The table shows the statistics of association between the analyzed phenotype of the patients (total number of severe manic relapses corrected for the total number of observation for each patient) and the number of manic relapses at specific timepoints (every 30 days from the beginning of the study) that is a more classical approach for these kind of studies but is related to a bigger number of missings (totally avoided with our phenotype) and clinical bias (e.g. more severe patients might have been seen more often compared to less severe ones.).

Table 2: Study of the correlation between the phenotype under analysis and the number of manic relapses at specific timepoints.

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