| |
TITLE |
Kind of study |
Main result |
REFERENCE |
| 1 |
The genetics of alcohol dependence. |
Review |
Genes involved in GABAergic, endogenous opioid, dopaminergic, cholinergic, and serotonergic transmission are selected as best candidates for AD related genes |
[35] |
| 2 |
Genome-wide association study of alcohol dependence:significant findings in African- and European-Americans including novel risk loci. |
GWAS |
16,087 AD subjects; ADH1B, ADH1C, ADH gene cluster, PDLIM5, METAP, rs1437396, between MTIF2 and CCDC88A may be associated with AD |
[36] |
| 3 |
Family-Based Association Analysis of Alcohol Dependence Criteria and Severity. |
GWAS |
118 extended European American families (n = 2,322 individuals); NALCN, OR51L1 may be associated with AD |
[37] |
| 4 |
Introduction to Deep Sequencing and Its Application to Drug Addiction Research with a Focus on Rare Variants. |
Review |
ALDH2 may be associated with AD |
[38] |
| 5 |
A genome-wide association study of behavioral disinhibition. |
GWAS |
7,188 Caucasian individuals clustered in 2,300 nuclear families; rs1868152 (intronic) associated with the use of illicit drugs |
[39] |
| 6 |
Association, interaction, and replication analysis of genes encoding serotonin transporter and 5-HT3 receptor subunits A and B in alcohol dependence. |
Candidate gene |
500 AD and 280 healthy control individuals of European descent; SLC6A4-HTR3A-HTR3B interact in affecting AD |
[40] |
| 7 |
Dosage transmission disequilibrium test (dTDT) for linkage and association detection. |
TDT |
Rs4903712 may affect AD behavior |
[41] |
| 8 |
A meta-analysis of two genome-wide association studies to identify novel loci for maximum number of alcoholic drinks. |
Meta-analysis of GWAS |
two GWAS using maxdrinks as an excessive alcohol consumption phenotype: one in 118 extended families (N = 2,322) selected from COGA,, and the other in a case-control sample (N = 2,593) derived from SAGE. Rs9523562 and rs67666182 were associated with AD. LMO1, AUTS2, INADL, HIP1 and PLCL1 were associated with alcohol related phenotypes. |
[42] |
| 9 |
Common biological networks underlie genetic risk for alcoholism in African- and European-American populations. |
GWAS re-analysis |
Chloride transporters and glycine metabolism genes are associated with AD |
[43] |
| 10 |
Replication of genome wide association studies of alcohol dependence: support for association with variation in ADH1C. |
GWAS |
808 alcohol-dependent cases and 1,248 controls; ADH1C may be associated with AD |
[44] |
| 11 |
Extended genetic effects of ADH cluster genes on the risk of alcohol dependence: from GWAS to replication. |
GWAS |
ADH1B may be associated with AD |
[45] |
| 12 |
Multi-species data integration and gene ranking enrich significant results in an alcoholism genome-wide association study. |
Mixed animal and GWAS in humans approach |
COGA and SAGE samples; brain responses to ethanol and neural adaptations genes are involved in AD |
[46] |
| 13 |
Using genetic information from candidate gene and genome-wide association studies in risk prediction for alcohol dependence. |
GWAS |
COGA and SAGE samples |
[47] |
| 14 |
Genome-wide association study identifies a potent locus associated with human opioid sensitivity. |
GWAS |
Family history was a better predictor of AD than genes |
[48] |
| 15 |
A genome-wide association study of alcohol-dependence symptom counts in extended pedigrees identifies C15orf53. |
GWAS |
Collaborative Study on the Genetics of Alcoholism sample; C15orf53 may be associated with AD |
[49] |
| 16 |
TACR1 genotypes predict fMRI response to alcohol cues and level of alcohol dependence. |
Imaging study |
326 individuals with alcohol use disorders; rs3771863, rs3755459, and rs1106855 (TACR1) predicted BOLD activation in response to alcohol cues |
[50] |
| 17 |
ANKRD7 and CYTL1 are novel risk genes for alcohol drinking behavior. |
GWAS |
1972 Caucasians in 593 nuclear families, 761 unrelated Caucasian subjects, and 2955 unrelated Chinese Hans; ANKRD7, CYTL1 may be associated with AD |
[51] |
| 18 |
Genetic influences on craving for alcohol. |
Candidate gene analysis and GWAS |
a sample of unrelated adults ascertained for alcohol dependence (N=3976); DRD3, ITGADmay be associated with AD (craving) |
[52] |
| 19 |
A novel, functional and replicable risk gene region for alcohol dependence identified by genome-wide association study. |
GWAS |
a discovery sample of 681 African-American (AA) cases with alcohol dependence and 508 AA controls were retested in a primary replication sample of 1,409 European-American (EA) cases and 1,518 EA controls; PHF3-PTP4A1 locus may be associated with AD |
[53] |
| 20 |
A haplotype analysis is consistent with the role of functional HTR1B variants in alcohol dependence. |
Candidate study |
136 Brazilian alcoholics of European descendent and 237 controls; rs11568817 (HTR1B) may be associated with AD |
[54] |
| 21 |
Genome-wide significant association between alcohol dependence and a variant in the ADH gene cluster. |
GWAS |
1333 male in-patients with severe AD according to the Diagnostic and Statistical Manual of Mental Disorders, 4th edition, and 2168 controls; ADH1B, ADH1C may be associated with AD |
[55] |
| 22 |
Genome-wide association study of alcohol dependence implicates KIAA0040 on chromosome 1q. |
GWAS |
4116 subjects (1409 European-American (EA) cases with AD, 1518 EA controls, 681 African-American (AA) cases, and 508 AA controls); TNN-KIAA0040 may be associated with AD |
[56] |
| 23 |
A quantitative-trait genome-wide association study of alcoholism risk in the community: findings and implications. |
GWAS |
3393 Australians with genome-wide SNP data; ANKS1A and TMEM108 may be associated with AD |
[57] |
| 24 |
Genome-wide association study of theta band event-related oscillations identifies serotonin receptor gene HTR7 influencing risk of alcohol dependence. |
GWAS |
1,064 unrelated individuals, ARID5A, HTR7 may be associated with event-related brain oscillations |
[59] |
| 25 |
Genome-wide association study of alcohol dependence implicates a region on chromosome 11. |
GWAS |
Collaborative Study on the Genetics of Alcoholismsample; SLC22A18, PHLDA2, NAP1L4, SNORA54, CARS, and OSBPL5 may be associated with AD |
[60] |
| 26 |
A genomewide association study of nicotine and alcohol dependence in Australian and Dutch populations. |
GWAS |
1224 cases and 1162 controls plus comorbid AD and ND, 599 cases and 488 controls; ARHGAP10, MARK1, DDX6, KIAA1409 may be associated with AD or ND |
[61] |
| 27 |
Genome-wide association study of alcohol dependence |
GWAS |
487 male inpatients with alcohol dependence, 1358 population-based control individuals; follow-up study included 1024 male inpatients and 996 age-matched male controls. CDH13 and ADH1C may be involved in AD |
[62] |
The table is a resumen of the studies analyzed to extract the initial subset of genes that showed a possible association with alcohol dependence phenotypes in last 10 years.
AD: Alcohol-dependence; ND: Nicotine-dependence
COGA: Collaborative Study on the Genetics of Alcoholism (