Step Variable R2 ΔR2 Cohen’s f2‡ F p value
RAVLT
total immediate recall
(model 1 – BDI-II total score)		 1


2

3
4
5		 Premorbid IQ, treatment sessions†, treatment content††, treatment focus††† poly drug use, past 24 hours alcohol use, gender, current anxiolytic, current antidepressant, age, age at leaving school.
Baseline BDI-II total score, baseline mean drinks/week, baseline heavy drinking days/week, baseline RAVLT total immediate recall.
Change in mean drinks/week baseline-12 months.
Change in heavy drinking days/week baseline-12 months.
Change in BDI-II total score baseline-12 months		 0.157


0.672

0.672
0.672
0.709		 0.157


0.514

0.000
0.000
0.037		 .0186


1.570

0.000
0.000
0.127		 0.746


15.665

0.038
0.008
4.696		 0.690


0.000***

0.847
0.931
0.037
RAVLT
total immediate recall
(model 2 – BDI-II subscale scores)		 5
6
7		 Change in BDI-II cognitive subscale
Change in BDI-II affective subscale
Change in BDI-II somatic subscale		 0.752
0.756
0.767		 0.080
0.004
0.011		 0.323
0.016
0.047		 11.924
0.634
1.624		 0.001**
0.431
0.211
RAVLT
delayed recall
(model 1 – BDI-II total score)		 1


2

3
4
5		 Premorbid IQ, treatment sessions†, treatment content††, treatment focus††† poly drug use, past 24 hours alcohol use, gender, current anxiolytic, current antidepressant, age, age at leaving school.
Baseline BDI-II total score, baseline mean drinks/week, baseline heavy drinking days/week, baselineRAVLT delayed recall.
Change in mean drinks/week baseline-12 months.
Change in heavy drinking days/week baseline-12 months.
Change in BDI-II total score baseline-12 months		 0.286


0.648

0.655
0.665
0.691		 0.286


0.362

0.007
0.011
0.025		 0.401


1.028

0.020
0.030
0.084		 1.605


10.283

0.744
1.203
3.042		 0.131


0.000***

0.394
0.280
0.089
RAVLT
delayed recall
(model 2 – BDI-II subscale scores)		 5
6
7		 Change in BDI-II cognitive subscale
Change in BDI-II affective subscale
Change in BDI-II somatic subscale		 0.721
0.724
0.733		 0.056
0.003
0.009		 0.201
0.011
0.034		 7.430
0.375
1.132		 0.010*
0.544
0.295
Digit Span
(model 1 – BDI-II total score)		 1


2

3
4
5		 Premorbid IQ, treatment sessions†, treatment content††, treatment focus††† poly drug use, past 24 hours alcohol use, gender, current anxiolytic, current antidepressant, age, age at leaving school.
Baseline BDI-II total score, baseline mean drinks/week, baseline heavy drinking days/week, baseline digit span.
Change in mean drinks/week baseline-12 months.
Change in heavy drinking days/week baseline-12 months.
Change in BDI-II total score baseline-12 months		 0.221


0.382

0.382
0.385
0.540

0.221


0.161

0.000
0.003
0.156

 0.284


0.261

0.000
0.005
0.337		 1.133


2.609

0.001
0.155
12.513		 0.360


0.050

0.973
0.696
0.001**
Digit Span
(model 2 – BDI-II subscale scores)		 5
6
7		 Change in BDI-II cognitive subscale
Change in BDI-II affective subscale
Change in BDI-II somatic subscale		 0.436
0.574
0.615		 0.052
0.138
0.041		 0.090
0.324
0.106		 3.412
11.661
3.686		 0.073
0.002**
0.063
†1 session versus 10 sessions; ††Alcohol versus depression focus; †††Integrated versus single-focus
‡Effect size attributable to the addition of variables at each step
* Significant at the 0.05 level (Bonferroni corrected); ** Significant at the 0.01 level (Bonferroni corrected); *** Significant at the 0.001 level (Bonferroni corrected)
Table 6: Multiple regression analyses with change in depression and alcohol use as predictors of change in memory.
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